来源：风湿病与关节炎,2019,8（6）:17-19,23.

膝骨关节炎与外周血IL-4、IL-6、IL-17A的相关性分析

（临床研究）

曾惠琼¹，黄新民¹，伍少霞²，熊力群¹，卢小平¹，叶志中¹

　　【摘　要】目的：比较膝骨关节炎患者及健康人群外周血中白细胞介素（IL）-4、IL-6、IL-17A的含量，研究IL-4、IL-6、IL-17A与膝骨关节炎严重程度的关系，探讨膝骨关节炎的发病机制。方法：选取膝骨关节炎患者67例为膝骨关节炎组，再选取同期体检的健康志愿者58例为健康对照组。检测2组外周血中IL-4、IL-6、IL-17A的水平，使用Lequesne指数评估骨关节炎的严重程度。结果：膝骨关节炎组外周血中IL-6、IL-17A含量较健康对照组高，差异有统计学意义（P < 0.05），IL-4水平与健康对照组比较，差异无统计学意义（P > 0.05）；膝骨关节炎组外周血中IL-6、IL-17A的水平与膝骨关节炎的严重程度呈正相关（r = 0.734，P < 0.01；r = 0.463，P < 0.05）。结论：膝骨关节炎患者外周血中IL-6、IL-17A的表达明显升高，并且与病变严重程度呈正相关，IL-6、IL-17A可能参与了膝骨关节炎的病理过程，阻断IL-6、IL-17A信号通路，有望减轻及改善患者膝关节的破坏。

　　【关键词】　骨关节炎，膝；白细胞介素-4；白细胞介素-6；白细胞介素-17A；相关性

Analysis of the Correlation Between Knee Osteoarthritis and IL-4,IL-6 and IL-17A in Peripheral Blood

ZENG Hui-qiong,HUANG Xin-min,WU Shao-xia,XIONG Li-qun,LU Xiao-ping,YE Zhi-zhong

　　【ABSTRACT】Objective:To compare the levels of IL-4,IL-6 and IL-17A in peripheral blood of patients with knee osteoarthritis and healthy people,to study the relationship between the levels of IL-4,IL-6 and IL-17A and the severity of knee osteoarthritis,and to explore the pathogenesis of knee osteoarthritis.Methods:Sixty-seven patients with knee osteoarthritis were selected as the knee osteoarthritis group,and 58 healthy volunteers were selected as the healthy control group.The levels of IL-4,IL-6 and IL-17A in peripheral blood of the two groups were detected,and the severity of osteoarthritis was assessed by Lequesne index.Results:The levels of IL-6 and IL-17A in the peripheral blood of the knee osteoarthritis group were higher than those of the healthy control group,with a statistical significance（P < 0.05）.There was no significant difference in the levels of IL-4 between the knee osteoarthritis group and the healthy control group（P > 0.05）.The levels of IL-6 and IL-17A in peripheral blood of the knee osteoarthritis group were positively correlated with the severity of knee osteoarthritis（r = 0.734,P < 0.01;r = 0.463,P < 0.05）.Conclusion:The expression of IL-6 and IL-17A in the peripheral blood of patients with knee osteoarthritis is significantly increased and positively correlated with the severity of the disease.IL-6 and IL-17A may be involved in the pathological process of knee osteoarthritis.Blocking IL-6 and IL-17A signaling pathways is expected to reduce and improve the damage of knee joint.

　　【Keywords】 osteoarthritis,knee;IL-4;IL-6;IL-17A;correlation