来源：风湿病与关节炎,2019,8（6）:13-16.

包头地区不同性别痛风患者临床特点分析（临床研究）

闫慧明，薛一萍，安　燕，张　雪

　　【摘　要】目的：分析包头地区不同性别痛风患者的临床特点。方法：对834例急性痛风患者的临床特征进行分析，根据不同性别分为2组，其中男性组749例，女性组85例，了解患者一般情况、生活方式、既往病史、临床表现，以及并发症、合并症等。结果：男性组体质量指数（BMI指数）和腹围较女性大，差异有统计学意义（P < 0.05）。男性以饮酒、吸烟、熬夜、剧烈活动、气温变化为诱因，女性以服用药物为诱因，差异有统计学意义（P < 0.05），两者均以含糖饮料和高嘌呤饮食为诱因，差异无统计学意义（P ﹥ 0.05）。男性患者更易合并高血压、糖尿病、高脂血症，差异有统计学意义（P < 0.05）；男性以足跖趾关节、踝关节、膝关节首发多见，女性以踝关节和手指关节首发多见，差异有统计学意义（P < 0.05）。Logistic多因素回归分析显示，性别、BMI指数、腹围、高嘌呤饮食与痛风有关，其中BMI指数、腹围、高嘌呤饮食是痛风危险因素，女性是痛风保护因素，差异有统计学意义（P < 0.05）。结论：痛风以男性多见，BMI指数高、腹围大，喜欢饮酒、吸烟、熬夜、高嘌呤饮食，以及代谢综合征是危险因素，男性以足跖趾关节、踝关节、膝关节首发多见，女性以踝关节和手指关节首发多见；女性是痛风保护因素。

　　【关键词】　痛风；高尿酸血症；性别；BMI指数；腹围；代谢综合征

Clinical Characteristics of Gout Patients of Different Genders in Baotou

YAN Hui-ming,XUE Yi-ping,AN Yan,ZHANG Xue

　　【ABSTRACT】Objective:To analyze the clinical characteristics of gout patients of different genders in Baotou.Methods:The clinical characteristics of 834 patients with acute gout were analyzed.They were divided into two groups according to gender,a male group（749 cases）and a female group（85 cases）,investigating their general condition,lifestyle,medical history,clinical manifestation,and complication.Results:BMI and abdominal circumference in the male group were larger than those of the female group,and the difference was statistically significant（P < 0.05）.Causes in the male group were drinking,smoking,staying up late,vigorous activities and temperature changes,while the cause in the female group was taking drugs,and the difference was statistically significant（P < 0.05）.Sugary drinks and high purine diet were two main causes for both groups,with no significant difference（P > 0.05）.Male patients were more likely to have hypertension,diabetes and hyperlipidemia,and the difference was statistically significant（P < 0.05）.Male patients were more likely to have the first onset in the toe-metatarsal joint,ankle joint and knee joint,and female patients were more likely to have the first onset in ankle joint and finger joint,the difference being statistically significant（P < 0.05）.Logistic multivariate regression analysis showed that sex,BMI,abdominal circumference and high purine diet were related to gout.BMI index,abdominal circumference and high purine diet were risk factors for gout,while women were protective factors for gout.The difference was statistically significant（P < 0.05）.Conclusion:Gout is more common in the male,especially in those with high BMI and large abdominal circumference and those liking drinking,smoking,staying up late and having high purine diet,and metabolic syndrome is the risk factor.Male patients were more likely to have the first onset in the toe-metatarsal joint,ankle joint and knee joint,and female patients were more likely to have the first onset in ankle joint and finger joint.Women were protective factors for gout.

　　【Keywords】 gout;hyperuricemia;sex;BMI;abdominal circumference;metabolic syndrome