来源：风湿病与关节炎,2023,12（5）:18-22.

类风湿关节炎合并2型糖尿病的临床特点（临床研究）

殷建美¹，孟凡雨¹，张昊喆¹，唐海倩¹，晏蔚田¹，凌　丽¹，杨显娜¹，彭江云²

　　【摘　要】目的：分析类风湿关节炎合并2型糖尿病的临床特点及其影响因素。方法：选取264例类风湿关节炎患者作为研究对象，根据是否合并2型糖尿病将患者分为观察组和对照组，记录2组患者的临床资料，比较2组实验室指标及关节受累情况。结果：观察组患者平均年龄大于对照组（P = 0.002）；观察组血尿酸、甘油三酯、低密度脂蛋白胆固醇、C反应蛋白、谷草转氨酶、IgG-RF值均高于对照组，差异有统计学意义（P < 0.05）；从关节受累情况来看，观察组骨质侵蚀、关节周围软组织肿胀、关节间隙狭窄的发生率显著高于对照组，差异有统计学意义（P < 0.05）；2组骨质疏松发生率比较，差异无统计学意义（P > 0.05）。结论：类风湿关节炎高龄患者更容易发生2型糖尿病，合并2型糖尿病的类风湿关节炎患者炎症指标相对较高，易伴随代谢综合征以及肝功能损伤的发生，且关节受累的发生率更高。

　　【关键词】　类风湿关节炎；2型糖尿病；代谢综合征；临床特点

Clinical Characteristics of Rheumatoid Arthritis with Type 2 Diabetes

YIN Jian-mei,MENG Fan-yu,ZHANG Hao-zhe,TANG Hai-qian,YAN Wei-tian,LING Li,YANG Xian-na,PENG Jiang-yun

　　【ABSTRACT】Objective:To analyze the clinical characteristics and influencing factors of rheumatoid arthritis with type 2 diabetes.Methods:Two hundred and six-four patients with rheumatoid arthritis were selected as the research object,and divided into the observation group and the control group according to whether they were combined with type 2 diabetes.The clinical data of the patients in the two groups were recorded,and the laboratory indicators and joint involvement in the two groups were compared.Results:The average age of patients in the observation group was older than that in the control group（P = 0.002）.The serum uric acid,triglyceride,low-density lipoprotein cholesterol,C-reactive protein,aspartate transaminase,and IgG RF in the observation group were higher than those in the control group,with a statistically significant difference（P < 0.05）.From the perspective of joint involvement,the incidence of bone erosion,soft tissue swelling around the joints,and joint space narrowing in the observation group was significantly higher than that in the control group,with a statistically significant difference（P < 0.05）.There was no statistically significant difference in the incidence of osteoporosis between the two groups（P > 0.05）.Conclusion:The elderly patients with rheumatoid arthritis are more likely to develop type 2 diabetes,and the rheumatoid arthritis patients with type 2 diabetes have relatively high inflammatory indicators,which are easily accompanied by metabolic syndrome and liver function damage,and the incidence of joint involvement is higher.

　　【Keywords】 rheumatoid arthritis;type 2 diabetes;metabolic syndrome;clinical characteristics