来源：风湿病与关节炎,2021,10（1）:12-14,36.

类风湿关节炎患者血管内皮生长因子的变化及其相关性分析（临床研究）

龚　雪¹，汪　元²

　　【摘　要】目的：观察类风湿关节炎（RA）患者血管内皮生长因子（VEGF）的变化，并探讨VEGF与其他指标和中医症状的相关性。方法：选取38例活动期RA患者（活动组）、22例缓解期RA患者（缓解组）和20例正常体检者（正常对照组），观察3组VEGF变化，并探讨RA患者VEGF数值与血小板计数（PLT）、类风湿因子（RF）、红细胞沉降率（ESR）、C反应蛋白（CRP）等指标和中医症状之间的关系。结果：活动组VEGF水平显著高于缓解组和正常对照组，缓解组VEGF水平显著高于正常对照组，差异有统计学意义（P < 0.01）。活动组VEGF与PLT、ESR、CRP、RF呈正相关（P < 0.05），与IgM呈负相关（P < 0.05）；缓解组VEGF与PLT、ESR、CRP呈正相关（P < 0.05）；活动组VEGF与关节肿胀、关节疼痛、肢体困倦、舌暗苔腻呈正相关（P < 0.05）；缓解组VEGF与关节肿胀、关节疼痛呈正相关（P < 0.05）。结论：RA患者的VEGF与所选指标及中医症状有相关性，表明VEGF可在一定程度上反映RA疾病活动度，对临床判断疾病情况及用药疗效有一定价值。

　　【关键词】　关节炎，类风湿；血管内皮生长因子；实验室指标；中医症状

Changes and Correlation of Vascular Endothelial Growth Factor in Patients with Rheumatoid Arthritis

GONG Xue,WANG Yuan

　　【ABSTRACT】Objective:To observe the changes of vascular endothelial growth factor（VEGF）in patients with rheumatoid arthritis（RA）,and to explore its correlation with other indicators and TCM symptoms.Methods:Thirty-eight active RA patients（the active group）,22 remission RA patients（the remission group）and 20 normal subjects（the normal control group）were selected to observe the changes of VEGF,and to explore the relationship between VEGF value,platelet count（PLT）,rheumatoid factor（RF）,erythrocyte sedimentation rate（ESR）,C reactive protein（CRP）and TCM symptoms in RA patients.Results:The VEGF level of RA patients in the active group was significantly higher than that in the remission group and the normal control group,and the VEGF level in the remission group was significantly higher than that in the normal control group,the difference being statistically significant（P < 0.01）.VEGF in the active group was positively correlated with PLT,ESR,CRP and RF（P < 0.05）,and negatively correlated with IgM（P < 0.05）.VEGF in the remission group was positively correlated with PLT,ESR and CRP（P < 0.05）.VEGF in the active group was positively correlated with joint swelling,joint pain,cumbersome fatigued limbs and dark and greasy tongue（P < 0.05）.VEGF in the remission group was positively correlated with joint swelling and joint pain（P < 0.05）.Conclusion:VEGF in RA patients is correlated with the selected indicators and TCM symptoms,which indicates that VEGF can reflect the disease activity of RA to a certain extent,and has a certain value in clinical judgment of disease situation and drug efficacy.　　【Keywords】 arthritis,rheumatoid;vascular endothelial growth factor;laboratory indicators;TCM symptoms