来源：风湿病与关节炎,2020,9（5）:10-13.

基于聚类分析研究膝骨关节炎中药组方的用药规律

（临床研究）

邱晓莲，李　鑫，曹建中

　　【摘　要】目的：挖掘中医药治疗膝骨关节炎的用药规律。方法：计算机检索中国知网（CNKI）、万方、维普（VIP）等数据库，纳入1979年1月1日至2019年5月1日中药治疗膝骨关节炎的临床研究文献，使用Excel 2003、SPSS Statistics 21.0统计软件，对符合纳入标准的中药进行频次分析和聚类分析。结果：在符合纳入标准的134首方剂中，使用频数≥15次的高频药物共32种，其中牛膝（96次，6.29%）、当归（75次，4.91%）、甘草（64次，4.19%）、熟地黄（56次，3.67%）、杜仲（53次，3.47%）、川芎（53次，3.47%）最为常见，使用最多的药物功效类别为祛风湿药（36次，20.57%）、补虚药（33次，18.86%）、活血化瘀药（24次,13.71%）、清热药（17次，9.71%）和解表药（13次，7.43%）。聚类分析得出杜仲-川芎-熟地黄-白芍-茯苓-当归-甘草-牛膝等3个聚类方。结论：历代医家治疗膝骨关节炎按照标本兼治的原则，以牛膝、当归、杜仲等活血化瘀类、补益类和祛风湿类药物为主，再依据辨证论治佐以清热类、理气类等药物。

　　【关键词】　骨关节炎，膝；频次分析；系统聚类分析；用药规律；数据挖掘

On the Rules of Prescribed Medication of Chinese Medicine to Treat Knee Osteoarthritis Based on Cluster Analysis

QIU Xiao-lian,LI Xin,CAO Jian-zhong

　　【ABSTRACT】Objective:To explore the rules of medication of Chinese medicine in the treatment of knee osteoarthritis.Methods:Databases such as CNKI,Wanfang and VIP were searched by computer to find the clinical research literature（from January 1,1979 to May 1,2019）on treating knee osteoarthritis with Chinese medicine.Excel 2003 and SPSS Statistics 21.0 were used to carry out frequency analysis and cluster analysis for selected Chinese medicine.Results:Among the 134 prescriptions,32 kinds of high frequency medicinals were used more than 15 times,including Niuxi（Radix Achyranthis Bidentatae,96 times,6.29%）,Danggui（Radix Angelicae Sinensis,75 times,4.91%）,Gancao（Radix et Rhizoma Glycyrrhizae,64 times,4.19%）,Shudihuang（Radix Rehmanniae Praeparata,56 times,3.67%）,Duzhong（Cortex Eucommiae,53 times,3.47%）,and Chuangxiong（Rhizoma Chuanxiong,53 times,3.47%）.The most common,and the most commonly used drug category are wind-dampness-dispelling medicinals（36 times,20.57%）,supplement-deficiency medicinals（33 times,18.86%）,blood-invigorating and stasis-dissolving medicinals（24 times,13.71%）,heat-clearing medicinals（17 times,9.71%）and exterior-releasing medicinals（13 times,7.43%）.Three cluster formulas were got from cluster analysis.Conclusion:According to the principle of treating knee osteoarthritis for the root and branch simultaneously,the physicians in the past mainly used blood-invigorating and stasis-dissolving medicinals such as Niuxi,Danggui and Duzhong,supplement medicinals and wind-dampness-dispelling medicinals,and modified them with heat-clearing medicinals and qi-regulating medicinals.

　　【Keywords】 osteoarthritis,knee;frequency analysis;system cluster analysis;medication rule;data mining