来源：风湿病与关节炎,2019,8（7）:8-12.

顽痹清丸联合常规西药治疗湿热痹阻证强直性脊柱炎28例临床观察（临床研究）

靳国强，赵　蕾，韩宗昌，孟宪杰

　　【摘　要】目的：观察顽痹清丸联合常规西药治疗湿热痹阻证强直性脊柱炎的临床疗效。方法：将56例湿热痹阻证强直性脊柱炎患者随机分为治疗组和对照组，每组28例。对照组口服美洛昔康胶囊和柳氮磺吡啶肠溶片治疗，治疗组在对照组的基础上加用顽痹清丸口服治疗。2组均以12周为1个疗程。观察2组治疗前后中医证候疗效、西医ASAS20疗效及红细胞沉降率（ESR）、C-反应蛋白（CRP）等实验室指标的变化情况，并比较2组不良反应发生情况。结果：中医证候疗效：治疗组临床痊愈3例，显效12例，有效10例，无效3例，总有效率为89.29%；对照组临床痊愈1例，显效13例，有效8例，无效6例，总有效率为78.57%。2组比较，差异有统计学意义（P < 0.05）。西医ASAS20疗效：治疗组ASAS20达标率为89.29%，对照组达标率为75.00%，治疗组明显优于对照组（P < 0.05）。治疗后，2组中医证候积分、ESR、CRP较治疗前均显著下降（P < 0.05），且治疗组下降幅度优于对照组（P < 0.05）。2组不良反应发生率比较，差异无统计学意义（P > 0.05）。结论：顽痹清丸联合常规西药治疗湿热痹阻证强直性脊柱炎疗效显著，不增加不良反应的发生，可显著控制患者病情，改善其生活质量。

　　【关键词】　脊柱炎，强直性；湿热痹阻证；顽痹清丸；临床疗效

Clinical Observation on 28 Cases of Ankylosing Spondylitis of Damp-heat-obstruction Syndrome Treated with Wanbiqing Wan（顽痹清丸）and Conventional Western Medicine

JIN Guo-qiang,ZHAO Lei,HAN Zong-chang,MENG Xian-jie

　　【ABSTRACT】Objective:To observe the clinical effect of Wanbiqing Wan（顽痹清丸）combined with conventional Western medicine in treating ankylosing spondylitis of damp-heat-obstruction syndrome.Methods:Fifty-six cases of ankylosing spondylitis with damp-heat-obstruction syndrome were randomly divided into a treatment group and a control group,28 cases in each group.The control group was treated with meloxicam capsule and sulfasalazine enteric-coated tablets,while the treatment group was treated with Wanbiqing Wan based on the treatment of the control group.The two groups were treated 12 weeks as a course.The changes of TCM syndromes,ASAS20,ESR,CRP and other laboratory indicators were observed before and after treatment,and the adverse reactions were compared between the two groups.Results:For the curative effect of TCM syndromes: in the treatment group,3 cases were clinical cured,12 cases were markedly effective,10 cases were effective and 3 cases were ineffective,the total effective rate being 89.29%;while in the control group,1 case was clinical cured,13 cases were markedly effective,8 cases were effective and 6 cases were ineffective,the total effective rate being 78.57%.There was a significant difference between the two groups（P < 0.05）.For the curative effect of ASAS20:the standard rate of ASAS20 in the treatment group was 89.29%,and that in the control group standard rate was 75.00%,and the treatment group was significantly better than the control group（P < 0.05）.After treatment,the scores of TCM syndromes,ESR and CRP in the two groups were significantly lower than those before treatment（P < 0.05）,and the decrease of treatment group was better than the control group（P < 0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P > 0.05）.Conclusion:Wanbiqing Wan combined with conventional western medicine is effective in treating ankylosing spondylitis with Damp-heat-obstruction syndrome.It does not increase the incidence of adverse reactions,and can significantly control patients' condition and improve their quality of life.

　　【Keywords】 spondylitis,ankylosing;damp-heat-obstruction syndrome;Wanbiqing Wan（顽痹清丸）;clinical efficacy