来源：风湿病与关节炎,2018,7（11）:5-9,16.

2300例类风湿关节炎患者红细胞计数及其相关参数的数据挖掘研究（临床研究）

孙艳秋¹，刘　健²，忻　凌²，万　磊²，方妍妍¹，文建庭¹，董文哲¹

　　【摘　要】目的：基于数据挖掘方法探究类风湿关节患者的红细胞计数（RBC）及其相关参数与炎症、免疫、代谢指标的相关性、关联性及危险因素。方法：整理类风湿关节炎住院患者的病例资料，研究其实验室指标，运用SPSS 22.0、SPSS Clementine 11.1 Aprior等统计学软件对指标进行相关性分析、关联性分析、二元Logistics回归分析。结果：①共纳入RA患者2300例，共有贫血患者1448例，其中轻度贫血1042例，中度贫血397例，重度贫血9例，极重度未发现。②相关性分析显示：RBC及其相关参数大多与白细胞计数（WBC）、补体C3、补体C4、三酰甘油（TG）、总胆固醇（TC）呈正相关（P < 0.05 或P < 0.01），与年龄、病程、红细胞沉降率（ESR）、超敏C-反应蛋白（hs-CRP）、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、类风湿因子（RF）等呈负相关（P < 0.05或P < 0.01）。③经关联性分析：RBC降低与WBC、IgM、C3、C4、TC、TG升高有明显关联性，血红蛋白（Hb）降低与WBC、IgM、C3、C4、TC、TG升高有明显关联性，红细胞压积（HCT）降低与WBC、C3、C4、TC、TG升高有明显关联性。④二元Logistic回归分析得出，C4、TG、TC升高是RBC下降的危险因素（OR > 1），WBC、C4、TG、TC升高是Hb下降的危险因素（OR > 1），WBC、TG、TC升高是HCT下降的危险因素（OR > 1）。结论：类风湿关节炎患者的RBC及其相关参数的下降，与炎症、免疫、代谢指标的升高具有相关性且部分指标呈有效的强关联性，WBC、C4、TC、TG升高可作为RBC及其相关参数值降低的危险因素，参与了类风湿关节炎的发病及活动，具体机制有待进一步研究。

　　【关键词】　关节炎，类风湿；贫血；红细胞计数及其相关参数；相关性分析；关联规则；数据挖掘

Data Mining of Red Blood Cell Count and Related Parameters in 2300 Patients with Rheumatoid Arthritis

SUN Yan-qiu,LIU Jian,XIN Ling,WAN Lei,FANG Yan-yan,WEN Jian-ting,

DONG Wen-zhe

　　【ABSTRACT】Objective:To explore the correlation and risk factors of erythrocyte count（RBC）and its related parameters with inflammatory,immune and metabolic indexes in patients with rheumatoid arthritis（RA）based on data mining.Methods:The data of patients with rheumatoid arthritis were collected,and related laboratory indexes were studied.Relativity analysis,correlation analysis and binary logistic regression analysis were performed with statistical softwares such as SPSS 22.0,SPSS Clementine 11.1 Aprior.Results:①A total of 2300 RA patients were included in the study,among which there were 1448 patients with anemia,including 1042 cases of mild anemia,397 of moderate anemia and 9 of heavy anemia.No severe anemia was found.②Relativity analysis showed that RBC and its related parameters were positively correlated with WBC,C3,C4,TG,TC（P < 0.05 or P < 0.01）,and negatively correlated with age,course of disease,ESR,hs-CRP,IgA,IgG and RF（P < 0.05 or P < 0.01）.③Correlation analysis showed that the decrease of RBC was significantly correlated with the increase of WBC,IgM,C3,C4,TC and TG,and the decrease of Hb was significantly correlated with the increase of WBC,IgM,C3,C4,TC and TG,and the decrease of HCT was significantly correlated with the increase of WBC,C3,C4,TC and TG.④The binary logistic regression analysis showed that the increase of C4,TG and TC was the risk factor for the decrease of RBC（OR > 1）,the increase of WBC,C4,TG and TC was the risk factor for the decrease of Hb（OR > 1）,and the increase of WBC,TG and TC was the risk factor for the decrease of HCT（OR > 1）.Conclusion:The decrease of RBC and its related parameters in patients with rheumatoid arthritis is correlated with the increase of inflammatory,immune and metabolic indexes,and some of them are strongly correlated with it.The increase of WBC,C4,TC and TG may be the risk factor for the decrease of RBC and its related parameters,involved in the pathogenesis and activity of rheumatoid arthritis.The  mechanism needs further study.

　　【Keywords】 arthritis,rheumatoid;anemia;red blood cell count and related parameters;relativity analysis;correlation rules;data mining