来源：风湿病与关节炎,2018,7（4）:16-20,59.

N-甲基-D-天冬氨酸受体与干燥综合征患者认知功能障碍的相关性研究（临床研究）

孙彩霞，臧　丽，裴　强，赵习德

　　【摘　要】目的：探索干燥综合征（SS）合并认知功能障碍的患者血清中N-甲基-D-天冬氨酸受体（NMDAR）表达量和临床价值。方法：采用ELISA法检测SS认知功能障碍组42例、SS认知功能正常组30例、健康对照组30例血清中NMDAR含量，对各组行实验室指标检查和简易精神状态量表（MMSE）评分，且在药物治疗3周后复查上述指标。结果：SS认知功能障碍组中血清NMDAR表达量（171.16±130.29）pg·mL^-1，显著高于SS认知功能正常组的（101.39±70.59）pg·mL^-1、健康对照组的（92.69±67.25）pg·mL^-1，差异有统计学意义（P < 0.05）；SS认知功能障碍组患者血清中NMDAR表达量治疗前高于治疗后，差异有统计学意义（t = 3.87，P < 0.05）；SS认知功能障碍组患者血清中NMDAR表达量和其MMSE评分呈负相关（r = -0.534，P < 0.05）。结论：NMDAR可作为一种临床指标应用于SS患者合并认知功能障碍早期诊断。

　　【关键词】　干燥综合征；认知功能障碍；N-甲基-D-天冬氨酸受体；相关性

Correlation between N-methyl-D-aspartate Receptor and Cognitive Dysfunction in Patients with Sjögren's Syndrome

SUN Cai-xia,ZANG Li,PEI Qiang,ZHAO Xi-de

　　【ABSTRACT】Objective:To explore the expression and clinical value of N-methyl-D-aspartate  receptor（NMDAR）in patients with Sjögren's syndrome（SS）complicated with cognitive dysfunction.Methods:Enzyme linked immunosorbent assay（ELISA）was used to test the serum levels of NMDAR in 42 cases in the cognitive dysfunction group,30 cases in the normal cognition group and 30 healthy controls.The laboratory indexes were recorded and the MMSE scores were evaluated in each group,and the above indexes were rechecked after three weeks of treatment.Results:The expression level of serum NMDAR in the cognitive dysfunction group（171.16±130.29）pg·mL^-1 was significantly higher than those in the normal cognition group（171.16±130.29）pg·mL^-1 and the healthy control group（92.69±67.25）pg·mL^-1,and the difference was statistically significant（P < 0.05）.The serum NMDAR expression in the cognitive dysfunction group was higher before treatment than that after treatment,and the difference was statistically significant（t = 3.87,P < 0.05）.The expression of NMDAR in serum in the cognitive dysfunction group was negatively correlated with its MMSE score（r = -0.534,P < 0.05）.Conclusion:NMDAR canbe used as a clinical indicator for early diagnosis of cognitive dysfunction in SS patients.

　　【Keywords】 Sjögren's syndrome;cognitive dysfunction;N-methyl-D-aspartate receptor;correlation