来源：风湿病与关节炎,2018,7（1）:29-31,57.

常规西药口服联合中药熏洗及功能锻炼治疗强直性脊柱炎34例临床观察（临床研究）

郭芫沅¹，郭文彬²，王惠颖¹

　　【摘　要】目的：观察常规西药口服联合中药熏洗及功能锻炼治疗强直性脊柱炎的临床疗效。方法：将68例强直性脊柱炎患者随机分为治疗组和对照组，每组34例。对照组给予柳氮磺吡啶肠溶片及洛索洛芬钠片口服治疗，治疗组在对照组基础上加用中药熏洗配合功能锻炼治疗。2组均以3个月为1个疗程。观察2组治疗前后视觉模拟评分法（VAS）评分、中医证候积分、晨僵时间、Bath强直性脊柱炎疾病活动性指数（BASDAI）、Bath强直性脊柱炎功能指数（BASFI）、脊柱活动度、C-反应蛋白（CRP）及红细胞沉降率（ESR）等。结果：治疗后，2组VAS评分、中医证候积分、晨僵时间、BASDAI、BASFI较治疗前均有改善（P < 0.05），且治疗组优于对照组（P < 0.05）。在临床体征及实验室指标方面，2组脊柱侧弯度、Schöber试验、胸廓活动度、枕墙距、指地距、CRP、ESR较治疗前均有较大改善（P < 0.05），但治疗后2组比较差异无统计学意义（P > 0.05）。结论：口服柳氮磺吡啶肠溶片和洛索洛芬钠片联合中药熏洗及功能锻炼治疗强直性脊柱炎患者可明显改善患者症状、体征，临床疗效满意，临床不良反应较少，值得推广应用。

　　【关键词】　脊柱炎，强直性；中药熏洗；功能锻炼；临床疗效

Clinical Observation on 34 Cases of Ankylosing Spondylitis Treated with Western Medicine Orally Combining Chinese Medicine Fumigation and Washing and Functional Exercise

GUO Yuan-yuan,GUO Wen-bin,WANG Hui-ying

　　【ABSTRACT】Objective:To observe the clinical efficacy of western medicine combining Chinese medicine fumigation and washing and functional exercise in the treatment of ankylosing spondylitis.Methods:Sixty-eight patients with ankylosing spondylitis were randomly divided into a treatment group and a control group,with 34 cases in each.The control group was treated with sulfasalazine enteric-coated tablets and loxoprofen,while the treatment group,based on the treatment for the control group,was treated with Chinese medicine fumigation and washing and functional exercise.The two groups were treated for three months as a course and observed,before and after treatment,on visual analogue scale（VAS）score,TCM syndrome score,time of morning stiffness,Bath ankylosing spondylitis disease activity index（BASDAI）,Bath ankylosing spondylitis functional index（BASFI）,spinal mobility,C-reactive protein（CRP）and erythrocyte sedimentation rate（ESR）.Results:After treatment,TCM syndrome score,VAS score,the time of morning stiffness,BASDAI and BASFI of the two groups were improved compared with those before treatment（P < 0.05）,and the treatment group was better than the control group（P < 0.05）.As for the clinical signs and laboratory indicators,spine curvature,Schöber Test,thoracic activity,occipital wall distance,finger distance,CRP and ESR were greatly improved compared with those before treatment（P < 0.05）,but there was no significant difference between the two groupsafter treatment（P > 0.05）.Conclusion:Sulfasalazine enteric-coated tablets and loxoprofen sodium tablets combining Chinese medicine fumigation and washing and functional exercise can obviously improve symptoms and signs of patients in the treatment of ankylosing spondylitis with satisfactory clinical efficacy and fewer clinical adverse reactions,which is worthy of popularization and application.

　　【Keywords】 spondylitis,ankylosing;Chinese medicine fumigation and washing;functional exercise;clinical efficacy