来源：风湿病与关节炎,2017,6（8）:27-31.

复方生地合剂治疗系统性红斑狼疮（阴虚内热型）的疗效

及安全性评价（临床研究）

吴菲雅¹，苏　晓²

　　【摘　要】目的：研究复方生地合剂在治疗阴虚内热型系统性红斑狼疮中增效减毒、撤减激素用量和改善症状等方面的优势。方法：将60例阴虚内热型系统性红斑狼疮患者随机分为治疗组和对照组，每组30例。均以中、小剂量糖质激素及羟氯喹治疗作为基础用药，治疗组加用复方生地合剂（生地黄30 g、生石膏30 g、忍冬藤30 g），对照组加用安慰剂（淮山药、焦糖）。治疗3个月，比较2组相关指标变化情况。结果：治疗3个月后，治疗组总有效率为83.33%，显著高于对照组的50.00%（P < 0.05）；治疗组中医证候积分、SLE-DAI积分均较治疗前改善（P < 0.05或P < 0.01），且治疗组优于对照组（P < 0.05）；治疗组激素用量较治疗前明显减少（P < 0.05）；治疗组抗ds-DNA抗体较治疗前降低（P < 0.05），对照组治疗前后比较差异无统计学意义（P > 0.05），且治疗后2组比较差异无统计学意义（P > 0.05）。治疗组不良反应事件发生率明显低于对照组（P < 0.05）。结论：复方生地合剂治疗阴虚内热型系统性红斑狼疮疗效明显，可显著降低中医证候积分、SLE-DAI积分，且安全性良好，能显著减少西药的毒副反应及并发症；更利于患者激素的撤减。

　　【关键词】　系统性红斑狼疮；阴虚内热型；复方生地合剂；增效减毒

On the Efficacy and Safety of Fufang Shengdi Heji（复方生地合剂）in the Treatment of Systemic Lupus Erythematosus of Yin Deficiency and Internal Heat Type

WU Fei-ya,SU Xiao

　　【ABSTRACT】Objective:To study the advantages of Fufang Shengdi Heji（复方生地合剂）in the treatmentof systemic lupus erythematosus of yin deficiency and internal heat type on the aspects of effect-enhancing and toxicity-reducing,reducing hormone dosage and improving symptoms.Methods:Sixty cases with systemic lupus erythematosus of yin deficiency and internal heat type were randomly divided into a treatment group and a control group,30 cases in each group.Medium and small doses of sugariness hormone and hydroxychloroquine were used as basic treatment.Based on that,the treatment group were treated with Fufang Shengdi Heji［shengdihuang（Rehmannia glutinosa Libosch.）30 g,shengshigao（gypsum fibrosum）30 g,rendongteng（Lonicera japonica Thunb.）30 g］,while the control group was treated with huaishanyao（Dioscorea opposita Thunb.）and caramel.After 3 months,the relative indexes of the two groups were compared.Results:After 3 months of treatment,the total efficiency of the treatment group was 83.33%,significantly higher than 50% of the control group（P < 0.05）.The TCM syndrome score and SLE-DAI score of the treatment group were improved compared with those before the treatment（P < 0.05 or P < 0.01）,and the treatment group was better than the control group（P < 0.05）.The amount of hormone used in the treatment group was less than before treatment（P < 0.05）.The ds-DNA antibody in the treatment groupwere decreased compared with those before the treatment（P < 0.05）,and the difference of the control group before and after treatment was not statistically significant（P > 0.05）,after the treatment the difference between the two groups was not statistically significant（P > 0.05）.The incidence of adverse events in the treatment group was significantly lower than that in the control group（P < 0.05）.Conclusion:Fufang Shengdi Heji has an obvious curative effect in the treatment of systemic lupus erythematosus of yin deficiency and internal heat type.It can significantly reduce the TCM syndrome integral,SLE-DAI integral,and the toxicity of and complications caused by western medicine.It is safe and can reduce the dosage of hormone.

　　【Keywords】 systemic lupus erythematosus;yin deficiency and internal heat type;Fufang Shengdi Heji（复方生地合剂）;effect-enhancing and toxicity-reducing