来源：风湿病与关节炎,2017,6（7）:11-14,28.

芙蓉膏联合中药治疗活动期强直性脊柱炎的临床数据挖掘及关联规则研究（临床研究）

黄　旦₁，刘　健2，何丽云3，忻　凌2，万　磊2，宋　倩1，郭锦晨1，周　巧1

　　【摘　要】目的：应用数据挖掘技术和关联规则分析运用芙蓉膏联合中药治疗活动期强直性脊柱炎的疗效及对免疫炎症指标的影响。方法：基于数据挖掘技术，对2012年6月至2016年6月安徽中医药大学第一附属医院风湿科住院的活动期强直性脊柱炎患者进行研究，以住院期间是否使用芙蓉膏为条件，分为芙蓉膏组和无芙蓉膏组，采用SPSS 22.0分析2组治疗前后免疫炎症指标变化情况，采用SPSS Clementine 12.0软件Aprior模块分析中药联合芙蓉膏与免疫炎症指标变化的关系。结果：①芙蓉膏组患者的免疫球蛋白A（IgA）、红细胞沉降率（ESR）、超敏C-反应蛋白（hs-CRP）、白细胞计数（WBC）均有所降低（P < 0.05或P < 0.01）；无芙蓉膏组患者的IgA、ESR、hs-CRP均有所降低（P < 0.01）；芙蓉膏组患者ESR、hs-CRP相对于无芙蓉膏组降低更明显（P < 0.05）。②本院风湿科论治湿热型AS常用药物一般分为4类：健脾祛湿药、清热药、活血化瘀药、祛风湿药。③关联规则分析得出：芙蓉膏、独活和芙蓉膏、黄芩与WBC、ESR、hs-CRP关联度较高。结论：芙蓉膏联合中药外用在改善活动期强直性脊柱炎患者炎症指标方面优于无芙蓉膏组，可作为风湿病的治疗方法进行推广。

　　【关键词】　脊柱炎，强直性；芙蓉膏；数据挖掘；关联规则

Study on the Treatment of Active Ankylosing Spondylitis with Furong Gao（芙蓉膏）Combining TCM by Clinical Data Mining and Association Rules

HUANG Dan,LIU Jian,HE Li-yun,XIN Ling,WAN Lei,SONG Qian,GUO Jin-chen,ZHOU Qiao

　　【ABSTRACT】Objective:To analyze the curative effect of Furong Gao（芙蓉膏）combined with TCM in the treatment of active ankylosing spondylitis by clinical data mining and association rules and its influence on immune and inflammatory indexes.Methods:Based on the data mining technology,a research was made for patients with active ankylosing spondylitis treated in the Department of Rheumatism of the First Affiliated Hospital of Anhui University of Chinese Medicine from June 2012 to June 2016.According to using Furong Gao or not,the patients were divided into a Furong Gao group and a control group without using Furong Gao.The software SPSS 22.0 was used to analyze the changes of immune inflammatory index of the two groups before and after treatment.The Aprior module in the software SPSS Clementine12.0 was used to analyze the relationship between Furong Gao combined with TCM and the changes of immune inflammatory index.Results:①IgA,ESR,hs-CRP and WBC in the Furong Gao group were decreased（P < 0.05 or P < 0.01）.IgA,ESR and hs-CRP in the control group were decreased（P < 0.01）.ESR and hs-CRP in the Furong Gao group were decreased more obviously than those in the control group（P < 0.05）.②The commonly used medicinal for ankylosing spondylitis in the Department of Rheumatism in the First Affiliated Hospital of Anhui University of Chinese Medicine were generally divided into four types:spleen-invigorating and dampness dispelling medicinal,heat-clearing medicinal,blood-activating and stasis-resolving medicinal and wind-damp-dispelling medicinal.③The association rules analysis showed that Furong Gao combined with dú huó or Furong Gao combined with huáng qín had a close correlation with WBC,ESR and hs-CRP.Conclusion:Furong Gao combined with Chinese medicine used externally is better than the control group in improving inflammatory index in patients with active ankylosing spondylitis,which can be promoted as a method to treat rheumatism treatment.

　　【Keywords】 spondylitis,ankylosing;Furong Gao（芙蓉膏）;data mining;association rules