来源：风湿病与关节炎,2024,13（4）:18-22,32.

青年系统性红斑狼疮患者心血管损害的临床特点及危险因素分析（临床研究）

邓思梅¹，陈　朗²，张　桦³

　　【摘　要】目的：分析青年系统性红斑狼疮患者合并心血管疾病的临床特点及危险因素。方法：收集2015年1月至2020年10月在中山大学附属第五医院住院治疗的131例20～40岁系统性红斑狼疮患者的临床资料，根据心电图、心脏彩超等结果将患者分为心血管疾病组（CVD组）和非心血管疾病组（n-CVD组），分别对2组的人口学资料、临床表现及实验室指标进行比较。将单因素分析中差异有统计学意义的指标纳入多因素Logistic回归分析中，筛选出系统性红斑狼疮合并心血管损害的危险因素。结果：与n-CVD组比较，CVD组血红蛋白、补体C3、白蛋白水平更低，SLEDAI-2000评分、D-二聚体水平及抗Ro-52抗体阳性率更高，差异有统计学意义（P < 0.05）。多因素Logistic回归分析显示，抗Ro-52抗体阳性是系统性红斑狼疮患者并发心血管疾病的危险因素（OR = 3.048，95%CI =［1.290，7.203］，P = 0.011）。结论：青年系统性红斑狼疮患者心血管损害很常见，抗Ro-52抗体阳性可能是系统性红斑狼疮合并心血管疾病的危险因素。

　　【关键词】　系统性红斑狼疮；青年；心血管疾病；抗Ro-52抗体；危险因素

An Analysis of Clinical Characteristics and Risk Factors of Cardiovascular Damage in Young Patients with Systemic Lupus Erythematosus

DENG Si-mei,CHEN Lang,ZHANG Hua

　　【ABSTRACT】Objective:To analyze the clinical characteristics and risk factors of cardiovascular disease（CVD）in young patients with systemic lupus erythematosus（SLE）.Methods:Clinical data of 131 SLE patients aged 20 to 40 who were hospitalized at the Fifth Affiliated Hospital Sun Yat-sen University from January 2015 to October 2020 were collected.Patients were divided into a cardiovascular disease group（CVD group）and a non-cardiovascular disease group（n-CVD group）based on results of electrocardiogram and echocardiography,et al.Demographic data,clinical manifestations,and laboratory indicators of both groups were compared.Statistically significant indicators from univariate analysis were incorporated into multivariate logistic regression analysis to identify risk factors for SLE combined with cardiovascular damage.Results:Compared with the n-CVD group,the CVD group had lower levels of hemoglobin,complement C3,and albumin,and higher SLEDAI-2000 scores,D-dimer levels,and positive rates of anti-Ro-52 antibodies.The difference between the two groups was statistically significant（P < 0.05）.Multivariate logistic regression analysis showed that anti-Ro-52 antibodies were a risk factor for concurrent CVD in SLE patients（OR = 3.048,95%CI = ［1.290,7.203］,P = 0.011）.Conclusion:Cardiovascular damage is common in young SLE patients,and anti-Ro-52 antibodies may be a risk factor for SLE combined with CVD.

　　【Keywords】 systemic lupus erythematosus;youth;cardiovascular disease;anti-Ro-52 antibody;risk factors