来源：风湿病与关节炎,2024,13（4）:12-17.

基于国家专利的中药外治复方治疗痛风性关节炎的用药规律研究（临床研究）

黄春霞¹，彭记棚¹，宋云云¹，李　丹¹，王敏慧¹，易寒知¹，陈昌明^1,2，姚血明^1,2

　　【摘　要】目的：基于中医传承计算平台V3.0挖掘国家专利数据库中治疗痛风性关节炎的中药外治复方，分析其组方用药规律。方法：检索国家知识产权局中国专利公布网站中治疗痛风性关节炎的专利中药外治复方数据，采用Excel 2021建立数据库，进行中药频次及功效统计，运用中医传承计算平台V3.0进行组方规律、潜在新处方等分析并进行复杂网络图展示。结果：筛选出治疗痛风性关节炎的专利中药复方269首，涉及中药431味。使用频次居前3位的药物分别是黄柏、红花、冰片，四气以温性为主，五味以苦为主，归经以肝经、脾经为主。中药类别以活血化瘀药、清热药、祛风除湿药为主。高频药物组合以“乳香、没药”“黄柏、大黄”“大黄、冰片”等为主。重要关联规则有“红花、没药→乳香”，“没药→乳香”，“黄柏、冰片→大黄”等。核心组合有“红花-当归-鸡血藤-羌活-防风-杜仲”等。方剂聚类分析得到可能的新处方组合5首。结论：专利中药外治复方主要通过活血化瘀、清热解毒、祛风除湿等功用治疗痛风性关节炎，在新药研发时，可考虑使用黄柏、红花、冰片等作为处方核心药物配伍加减。

　　【关键词】　痛风性关节炎；中药外治复方；专利；数据挖掘；中医传承计算平台

A Study on the Medication Rules of TCM External Treatment Formula for Gouty Arthritis Based on National Patents

HUANG Chun-xia,PENG Ji-peng,SONG Yun-yun,LI Dan,WANG Min-hui,YI Han-zhi,CHEN Chang-ming,YAO Xue-ming

　　【ABSTRACT】Objective:Based on the traditional Chinese medicine（TCM）inheritance computing platform V3.0,this study aims to explore the TCM external treatment formulas for gouty arthritis in the national patent database,and analyze their medication rules.Methods:The data of external treatment prescriptions of patent Chinese medicine for gouty arthritis in the Chinese patent publication website of the China National Intellectual Property Administration were retrieved,and a database was established in Excel 2021 to conduct statistics on the frequency and efficacy of Chinese medicine.The traditional Chinese medicine inheritance computing platform V3.0 was used to analyze the rules of prescri-ption and potential new prescriptions,and display complex network diagrams.Results:Two hundred and sixty-nine patented TCM formulas were screened for the treatment of gouty arthritis,involving 431 Chinese medicines.The top three medicines with the highest frequency of use are Huangbai（Cortex Phellodendri Chinensis）,Honghua（Flos Carthami）,and Binpian（Borneolum Syntheticum）.Among the four qi,warm is the main one;among the five flavors,bitter,and of the channel entry,the liver and spleen channels.The main Chinese medicines are those that activate blood,remove stasis,clear heat,dispel wind and eliminate dampness.The high-frequency medicinal combinations mainly include "Ruxiang（Olibanum）,Moyao（Myrrha）" "Huangbai（Cortex Phellodendri Chinensis）,Dahuang（Radix et Rhizoma Rhei）" "Dahuang（Radix et Rhizoma Rhei）,Bingpian（Borneolum Syntheticum）" Important association rules include "Honghua（Flos Carthami）,Moyao（Myrrha）→Ruxiang（Olibanum）" "Moyao（Myrrha）→Ruxiang（Olibanum）" and "Huangbai（Cortex Phellodendri Chinensis）,Bingpian（Borneolum Syntheticum） → Dahuang（Radix et Rhizoma Rhei）".The core combinations include "Honghua（Flos Carthami）-Danggui（Radix Angelicae Sinensis）-Jixueteng（Caulis Spatholobi）-Qianghuo（Rhizoma et Radix Notopterygii）-Fangfeng（Radix Saposhnikoviae）-Duzhong（Cortex Eucommiae）".Five possible new prescription combinations were identified through formula clustering analysis.Conclusion:Patented TCM external treatment formulas mainly treat gouty arthritis through functions such as promoting blood circulation and removing blood stasis,clearing heat and resolving toxins,dispelling wind and eliminating dampness.When developing new medicines,it is possible to consider using Huangbai,Honghua,Bingpian as the core prescription medicines together with modifications.

　　【Keywords】 gouty arthritis;TCM external treatment formula;patents;data mining;traditional Chinese medicine inheritance computing platform