来源：风湿病与关节炎,2024,13（3）:24-27,48.

381例干燥综合征的合并病及其影响因素的研究（临床研究）

李湘媛¹，李其越¹，曾王星¹，袁盛河¹，殷建美¹，孟凡雨¹，张昊喆¹，彭江云²

　　【摘　要】目的：总结干燥综合征患者合并病的临床症状，并分析其相关影响因素，为临床预防与治疗本病提供依据与方法。方法：分析云南省中医医院381例住院干燥综合征患者的合并病，总结干燥综合征合并病的临床特点。结果：干燥综合征患者合并病中骨骼系统疾病230例（60.37%），内分泌系统疾病195例（51.18%），肺部疾病189例（49.60%），心血管系统疾病149例（39.11%），眼部疾病50例（13.12%），其他疾病：慢性胃炎74例（19.43%），脂肪肝57例（14.96%）。结论：干燥综合征的合并病发生率高。干燥综合征主要为外分泌腺灶性淋巴细胞浸润，可引起多种系统疾病。专科医生须整体分析、多角度评估患有合并病的干燥综合征患者，采取有效措施及时预防、发现和处理干燥综合征患者合并病及有关危险因素，制定更具体、有效的治疗方针。

　　【关键词】　干燥综合征；合并病；临床特点；影响因素

Study on the Comorbidities and Influencing Factors of 381 Cases of Sjögren's Syndrome

LI Xiang-yuan,LI Qi-yue,ZENG Wang-xing,YUAN Sheng-he,YIN Jian-mei,MENG Fan-yu,ZHANG Hao-zhe,PENG Jiang-yun

　　【ABSTRACT】Objective:To summarize the clinical symptoms of comorbidities in patients with Sjögren's syndrome and analyze the related influencing factors,providing a certain basis and method for prevention and treatment in clinical practice.Methods:Analyzed the comorbidities of 381 hospitalized patients with Sjögren's syndrome at the First Affiliated Hospital of Yunnan University of Chinese Medicine,and summarized their clinical characteristics.Results:There were 230 cases（60.37%）of skeletal system diseases,195 cases（51.18%）of endocrine system diseases,189 cases（49.60%）of lung diseases,149 cases（39.11%）of cardiovascular system diseases,50 cases（13.12%）of eye diseases,74 cases（19.43%）of chronic gastritis and 57 cases（14.96%）of fatty liver.Conclusion:The incidence of comorbidities in Sjögren's syndrome is high.Sjögren's syndrome is mainly characterized by focal lymphocyte infiltration in exocrine glands,which can cause various systemic diseases in patients.Medical specialists need to conduct a comprehensive analysis,evaluate from multiple perspectives,take effective measures to prevent,detect,and deal with comorbidities and related risk factors in a timely manner,developing more specific and effective treatment policies.

　　【Keywords】 Sjögren's syndrome;comorbidities;clinical characteristics;influence factor