来源：风湿病与关节炎,2021,10（3）:33-37.

石家庄地区强直性脊柱炎证型分布及病情活动度研究（调查研究）

路占忠，刘进子，陈　琛，段皓云，付素兰

　　【摘　要】目的：分析石家庄地区强直性脊柱炎中医证型分布特点及病情活动情况。方法：选取石家庄市第三医院风湿免疫科门诊及住院强直性脊柱炎患者，采集病史及相关信息，辨证为肾虚督寒证、肾虚湿热证、瘀血阻络证、邪痹肢节证、邪及肝肺证、邪郁化热证。分析中医证候分布及家族史、潮湿环境接触情况、Bath强直性脊柱炎疾病活动指数（BASDAI）、红细胞沉降率（ESR）、超敏C反应蛋白（hs-CRP）、D-二聚体（DD）等疾病活动指标情况。结果：共收集符合标准的强直性脊柱炎患者122例，证候分布情况肾虚督寒证比例最高（39.34%），其他依次为瘀血阻络证（23.77%），肾虚湿热证（13.11%），邪郁化热证（10.66%），邪痹肢节证（8.20%），邪及肝肺证（4.92%）不同证型患者的年龄、病程、BASDAI、ESR、hs-CRP、DD比较，差异均有统计学意义（P < 0.01），肾虚督寒证多指标升高明显。结论：肾虚督寒证病情活动明显，且为石家庄地区强直性脊柱炎分布的主要证型，可能为临床诊治的主要标靶证型。

　　【关键词】　强直性脊柱炎；证型分布；病情活动度；石家庄地区

Study on Syndrome Type Distribution and Disease Activity of Ankylosing Spondylitis in Shijiazhuang Area

LU Zhan-zhong,LIU Jin-zi,CHEN Chen,DUAN Hao-yun,FU Su-lan

　　【ABSTRACT】Objective:To analyze the distribution characteristics of TCM Syndrome Type distribution and disease activity of ankylosing spondylitis in Shijiazhuang area.Methods:Patients with ankylosing spondylitis were recruited from the Department of Rheumatology and Immunology of Shijiazhuang Third Hospital,and their medical history and related information were collected.The syndrome differentiation results were as follows:kidney deficiency and Dumai coldness syndrome,kidney deficiency and damp heat syndrome,blood stasis blocking collaterals syndrome,pathogenic bi in limb joint syndrome,pathogens invading liver and lung syndrome,and pathogenic constraint transforming into heat syndrome.The distribution of TCM syndromes,family history,wet environment exposure,Bath Ankylosing Spondylitis Disease Activity Index（BASDAI）,erythrocyte sedimentation rate（ESR）,high sensitivity C-reactive protein（hs-CRP）,D-Dimer（DD）and other disease activity indicators were analyzed.Results:A total of 122 patients with ankylosing spondylitis were collected.The highest proportion of syndrome distribution was kidney deficiency and Dumai coldness syndrome（39.34%）,followed by blood stasis blocking collaterals syndrome（23.77%）,kidney deficiency and damp heat syndrome（13.11%）,pathogenic constraint transforming into heat syndrome（10.66%）,pathogenic bi in limb joint syndrome（8.20%）,pathogens invading liver and lung syndrome（4.92%）.There were significant differences in age,course of disease,BASDAI,ESR,hs-CRP and DD among patients with different syndrome types（P < 0.01）.Conclusion:The disease activity of kidney deficiency and Dumai coldness syndrome syndrome is obvious,and it is the main syndrome type of ankylosing spondylitis in Shijiazhuang area,which may be the main target syndrome type of clinical diagnosis and treatment.

　　【Keywords】 ankylosing spondylitis;syndrome type distribution;disease activity;Shijiazhuang area