来源：风湿病与关节炎,2020,9（6）:21-23,31.

新身痛逐瘀合剂联合美洛昔康胶囊治疗强直性脊柱炎23例临床观察（临床研究）

岳　月，于　静，高明利

　　【摘　要】目的：观察新身痛逐瘀合剂联合美洛昔康胶囊治疗强直性脊柱炎的临床疗效。方法：使用随机平行对照方法，将46例强直性脊柱炎患者按病历号抽签随机分为治疗组和对照组，每组23例。对照组给予美洛昔康胶囊（每次15 mg，每日1次）口服，治疗组在对照组治疗基础上加用新身痛逐瘀合剂（每次50 mL，每日2次）口服。2组均以4周为1个疗程。观察2组临床疗效，以及治疗前后Bath强直性脊柱炎疾病功能指数（BASFI指数）、Bath强直性脊柱炎疾病活动指数（BASDAI指数）、脊柱痛视觉模拟评分法（VAS）评分、患者总体评分、C-反应蛋白（CRP）水平。结果：治疗组痊愈8例，显效6例，有效6例，无效3例，总有效率为86.95%；对照组痊愈5例，显效7例，有效5例，无效6例，总有效率为73.91%。2组比较，差异有统计学意义（P < 0.05）。治疗后，2组患者BASFI指数、BASDAI指数、VAS评分、患者总体评分、CRP较治疗前均有改善（P < 0.05）；除CRP外，其余指标治疗组均优于对照组（P < 0.05）。结论：新身痛逐瘀合剂联合美洛昔康胶囊治疗强直性脊柱炎疗效显著，值得推广。

　　【关键词】　脊柱炎，强直性；新身痛逐瘀合剂；美洛昔康胶囊；随机平行对照研究；临床疗效

Clinical Observation on 23 Cases of Ankylosing Spondylitis Treated with Xin Shentong Zhuyu Heji（新身痛逐瘀合剂）and Meloxicam Capsule

YUE Yue,YU Jing,GAO Ming-li

　　【ABSTRACT】Objective:To observe the clinical effect of Xin Shentong Zhuyu Heji（新身痛逐瘀合剂）combined with meloxicam capsule in the treatment of ankylosing spondylitis.Methods:Forty-six patients with ankylosing spondylitis were randomly divided into a treatment group and a control group according to the hospitalizing number,23 cases in each group.The control group was given meloxicam capsule（15 mg each time,once a day）,and the treatment group was treated with Xin Shentong Zhuyu Heji（50 mL each time,twice a day）based on the treatment for the control group.Both group were treated for four weeks as a a course of treatment.The clinical effects,as well as BASFI,BASDAI,VAS,the patient's overall score,and CRP of the two groups before and after treatment were observed.Results:In the treatment group,8 cases were recovered,6 cases were markedly effective,6 cases were effective,3 cases were ineffective,and the total effective rate was 86.95%;while in the control group,5 cases were recovered,7 cases were markedly effective,5 cases were effective,6 cases were ineffective,and the total effective rate was 73.91%.The difference between the two groups was statistically significant（P < 0.05）.After treatment,BASFI,BASDAI,VAS,overall score and CRP of the two groups were all improved（P < 0.05）,and except CRP,the other indexes in the treatment group were better than those in the control group（P < 0.05）.Conclusion:Xin Shentong Zhuyu Heji combined with meloxicam capsule is effective in the treatment of ankylosing spondylitis,worthy of popularization.

　　【Keywords】 spondylitis,ankylosing;Xin Shentong Zhuyu Heji（新身痛逐瘀合剂）;meloxicam capsule;randomized parallel control study;clinical efficacy