来源：风湿病与关节炎,2020,9（3）:12-15,21.

急性痛风性关节炎患者感受的变化与免疫、炎症、代谢指标相关性研究（临床研究）

孙广瀚¹，刘　健²，龙　琰¹，鲍丙溪¹，张　颖¹

　　【摘　要】目的：探讨急性痛风性关节炎患者感受的变化与免疫、炎症、代谢指标相关性。方法：将57例急性痛风性关节炎患者采用调查问卷的方式，获得生活质量量表SF-36、Bath功能指数（BASFI）、Bath整体指数（BAS-G）、焦虑自评量表（SAS）、抑郁自评量表（SDS）各项积分，统计患者生活质量各维度积分，同时分析患者的生活质量各维度积分［生理机能（PF）、生理职能（RP）、躯体疼痛（BP）、一般健康状况（GH）、活力（VT）、社会功能（SF）、情感职能（RE），以及精神健康（MH）］与SF-36、视觉模拟评分法（VAS）评分、SAS积分、SDS积分和实验室指标［免疫球蛋白（IgA、IgM、IgG）、红细胞沉降率（ESR）、超敏C-反应蛋白（hs-CRP）、胆固醇（TC）、三酰甘油（TG）、尿酸（UA）、低密度脂蛋白（LDL）、同型半胱氨酸（Hcy）等］的相关性。结果：①PF与hs-CRP呈负相关（P < 0.01），与TG、UA、Hcy、SDS呈正相关（P < 0.05）；BP与TG、UA、Hcy、SDS呈正相关（P < 0.05），与hs-CRP呈负相关（P < 0.05）；GH与TG呈正相关（P < 0.05）；VT与TG呈正相关（P < 0.05）；SF与TG呈正相关（P < 0.01）；RE与TG呈正相关（P < 0.05）；生活质量各维度与其他指标无相关性（P ﹥ 0.05）。②SAS升高与hs-CRP、ESR、LDL升高有明显关联性；SDS升高与TC、ESR、UA升高有明显关联性。结论：患者生活质量显著下降与疾病的活动、躯体的疼痛、生理功能的受限、焦虑抑郁的情绪、免疫、炎性反应、代谢关系密切，其中与代谢尤为密切，对提高患者生活质量提供了数据上的支持。

　　【关键词】　急性痛风性关节炎；患者感受；相关性分析

Correlation between the Changes of Patient Self-perceive and the Indexes of Immunity,Inflammation and Metabolism in Patients with Acute Gouty Arthritis

SUN Guang-han,LIU Jian,LONG Yan,BAO Bing-xi,ZHANG Ying

　　【ABSTRACT】Objective:To explore the correlation between patient self-perceive with acute gouty arthritis and the indexes of immunity,inflammation and metabolism.Methods:Fifty-seven patients with acute gouty arthritis were investigated by questionnaire to get the scores of SF-36,BASFI,BAS-G,SAS and SDS,and the scores of each dimension of patients' quality of life were counted.Meanwhile,the correlation between the scores of each dimension of patients' quality of life（PF,RP,BP,GH,VT,SF,RE and MH）and SF-36,VAS,SAS,SDS and lab indexes（IGA,IgM,IgG,ESR,hs-CRP,TC,TG,UA,LDL and Hcy）was analyzed.Results:①PF was negatively correlated with hs-CRP（P < 0.01）and positively correlated with TG,UA,Hcy and SDS（P < 0.05）;BP was positively correlated with TG,UA,Hcy and SDS（P < 0.05）,and negatively correlated with hs-CRP（P < 0.05）;GH was positively correlated with TG（P < 0.05）;VT was positively correlated with TG（P < 0.05）;SF was positively correlated with TG（P < 0.01）;RE was positively correlated with TG（P < 0.05）,and there was no correlation between quality of life and other indicators（P﹥ 0.05）.②The increase of SAS was significantly related to the increase of hs-CRP,ESR and LDL,and the increase of SDS was significantly related to the increase of TC,ESR and UA.Conclusion:The quality of life of patients is significantly decreased,which is closely related to the activity of disease,the pain of body,the limitation of physiological function,the emotion of anxiety and depression,immunity,inflammatory reaction and metabolism,especially to metabolism,which provides data support for improving the quality of life of patients.

　　【Keywords】 acute gouty arthritis;patient self-perceive;correlation analysis