来源：风湿病与关节炎,2020,9（2）:24-26.

栀黄止痛散外敷联合依托考昔治疗痛风性关节炎急性期30例临床观察（临床研究）

张英杰¹，王上增²，沈锦涛²

　　【摘　要】目的：观察栀黄止痛散外敷联合依托考昔治疗痛风性关节炎急性期的临床疗效。方法：将60例痛风性关节炎急性期患者随机分为治疗组和对照组，每组30例。对照组口服依托考昔治疗，治疗组在对照组治疗基础上给予院内制剂栀黄止痛散外敷。2组均以2周为1个疗程。观察2组患者临床疗效，以及治疗前后疼痛视觉模拟评分法（VAS）评分、血尿酸（BUA）、红细胞沉降率（ESR）、C-反应蛋白（CRP）。结果：治疗组治愈21例，好转7例，无效2例，总有效率为93.33%；对照组治愈17例，好转4例，无效9例，总有效率为70.00%。2组比较，差异有统计学意义（P < 0.05）。治疗后，2组VAS评分、BUA、ESR、CRP较治疗前均有下降（P < 0.05），且治疗组优于对照组（P < 0.05）。结论：栀黄止痛散外敷联合依托考昔对于控制痛风性关节炎急性期具有良好的疗效。

　　【关键词】　痛风性关节炎；急性期；栀黄止痛散；外敷；依托考昔；临床疗效

Clinical Observation on Treating 30 Cases of Acute Attack of Gouty Arthritis by External Application of Zhihuang Zhitong San（栀黄止痛散）Combined with Etocoxib

ZHANG Ying-jie,WANG shang-zeng,SHEN Jin-tao

　　【ABSTRACT】Objective:To observe the clinical effect of Zhihuang Zhitong San（栀黄止痛散）on acute attack of gouty arthritis.Methods:Sixty patients with acute attack of gouty arthritis were randomly divided into a treatment group and a control group,30 cases in each group.The control group was treated with etocoxib,and the treatment group was treated with Zhihuang Zhitong San based on the treatment for the control group.Both groups were treated for 2 weeks.The clinical effect,VAS,BUA,ESR and CRP of the two groups were observed before and after treatment.Results:In the treatment group,21 cases were recovered,7 cases were improved,2 cases were ineffective,and the total effective rate was 93.33%.In the control group,17 cases were recovered,4 cases were improved,9 cases were ineffective,and the total effective rate was 70.00%.The difference between the two groups was statistically significant（P < 0.05）.After treatment,the VAS,BUA,ESR and CRP of the two groups were lower than those before treatment（P < 0.05）,and the treatment group was better than the control group（P < 0.05）.Conclusion:Zhihuang Zhitong San combined with etocoxib has a good effect on the control of acute attack of gouty arthritis.

　　【Keywords】 gouty arthritis;acute stage;Zhihuang Zhitong San（栀黄止痛散）;external application;etocoxib;clinical effeicacy