来源：风湿病与关节炎,2020,9（1）:21-24,33.

一贯煎治疗干燥综合征临床疗效及安全性的系统评价

（循证研究）

韩思宇，苑　艺，杨姝，林绿萍，蔡美玲，袁梓哲，李多多

　　【摘　要】目的：系统评价一贯煎治疗干燥综合征临床疗效及安全性。方法：计算机检索PubMed、The Cochrane Library、EMbase、中国知网、维普和万方等数据库，检索时间截至2019年4月30日，收集一贯煎治疗干燥综合征的随机对照试验。由2位研究人员单独筛选文献、提取资料，分析纳入文献的偏倚风险后，采用RevMan 5.3软件进行Meta分析。结果：共纳入6个研究，均为中文文献。Meta分析显示，一贯煎治疗组临床疗效明显优于对照组，差异有统计学意义（OR = 4.11，95%CI =［2.30，7.34］，P < 0.000 01）。共有2个研究提及不良反应，且治疗组不良反应例数少于对照组。结论：一贯煎治疗干燥综合征临床有效，且不易引起不良反应。因本研究纳入文献量少，西药种类繁多，受纳入文献方法学质量及干预措施不同等条件的局限，上述结论需要进一步实施更多高质量、样本量大的随机对照试验验证。

　　【关键词】　干燥综合征；一贯煎；系统评价；随机对照试验

A Systematic Evaluation of the Clinical Efficacy and Safety of Yiguanjian（一贯煎）in the Treatment of Sjögren's Syndrome

HAN Si-yu,YUAN Yi,YANG Shu-yue,LIN Lü-ping,CAI Mei-ling,YUAN Zi-zhe,LI Duo-duo

　　【ABSTRACT】Objective:To systematically evaluate the clinical efficacy and safety of Yiguanjian（一贯煎）in the treatment of Sjögren's syndrome.Methods:The PubMed,the Cochrane Library,EMBASE,CNKI,VIP and Wanfang databases were searched by computer to retrieve the randomized controlled trials（search time up to April 30,2019）for the treatment of Sjögren's syndrome.Two researchers screened literature,extracted data separately,analyzed the bias risk of the included literature,and then used software Revman 5.3 to make a Meta-analysis.Results:Six studies were included,all of which were Chinese literature.Meta analysis showed that the clinical effect of the treatment group treated with Yiguanjian was significantly better than that of the control group and the difference was statistically significant（OR = 4.11,95%CI =［2.30，7.34］,P < 0.000 01）.Adverse reactions were mentioned in two studies,and the adverse reactions in the treatment group was fewer than those in the control group.Conclusion:Yiguanjian has clinical effects in the treatment of Sjögren's syndrome,and it is not easy to cause adverse reactions.Due to the limitations of the small amount of literature,various kinds of Western medicine,different qualities of literature methodology and intervention measures,the above conclusions need to be further verified by more randomized controlled trials with good quality and large sample size.

　　【Keywords】 Sjögren's syndrome;Yiguanjian（一贯煎）;systematic evaluation;randomized controlled trial