来源：风湿病与关节炎,2018,7（6）:30-32.

环孢素A与利可君序贯治疗原发性合并外周血白细胞减少的临床观察（临床研究）

刘传慧，刘　璐，潘建康

　　【摘　要】目的：观察环孢素A与利可君序贯治疗原发性合并外周血白细胞减少的临床疗效。方法：选取60例原发性患者，入院实验室检查外周血白细胞（2.5～3.5）×10⁹·L^-1，随机分为A组和B组，每组30例。A组给予利可君每日60 mg，1个月后复查外周血白细胞；若升至3.5×10⁹·L^-1以上，给予环孢素A每日50 mg，治疗3个月后复查外周血白细胞。B组给予醋酸泼尼松每日15 mg，1个月后复查外周血白细胞；若升至3.5×10⁹·L^-1以上，给予环孢素A每日50 mg，治疗3个月后复查外周血白细胞。2组患者在3个月内逐渐减停利可君或醋酸泼尼松。结果：1个月后，A组26例、B组27例外周血白细胞升至3.5×10⁹·L^-1以上，均给予环孢素A每日50 mg治疗；3个月后，A组21例、B组23例外周血白细胞保持在3.5×10⁹·L^-1以上。结论：利可君治疗原发性干燥综合征合并外周血白细胞减少有效。

　　【关键词】　原发性利可君；环孢素A；外周血白细胞

Clinical Observation on Treating Primary Sjögren's Syndrome Complicating Peripheral Leukocyte Depletion with Cyclosporine A and Leucoson Tablets Sequential Therapy

LIU Chuan-hui,LIU Lu,PAN Jian-kang

　　【ABSTRACT】Objective:To investigate the clinical efficacy of cyclosporine A and Leucoson Tablets sequential therapy in the treatment of primary Sjögren's syndrome complicating peripheral leukocyte reduction.Methods:Sixty patients with primary Sjögren's syndrome were selected and randomly divided into group A and group B after their peripheral blood leucocytes（2.5～3.5）×10⁹·L^-1 were examined in the laboratory,with thirty cases in each group.Group A was given Leucoson Tablets（180 mg）daily.If their peripheral blood leukocytes were no less than 3.5×10⁹·L^-1,they would be given cyclosporine A（50 mg）daily and reexamined after three months of treatment.Group B was given 15 mg of prednisone per day,and 1 month later,the peripheral blood leukocytes were reexamined.If their peripheral blood leukocytes were up to 3.5×10⁹·L^-1,50 mg of cyclosporin A would be given each day.The peripheral blood leukocytes were reviewed after 3 months of treatment.During the 3 month,patients in the two groups were gradually given less or stopped taking Leucoson Tablets or prednisone.Results:One month later,peripheral blood leukocytes in 26 cases of group A and 27 cases of group B rose no less than 3.5×10⁹·L^-1.They were all treated with cyclosporine A（50 mg）per day.Three months later,peripheral blood leukocytes in 21 cases of group A and 23 cases of Group B were no less than 3.5×10⁹·L^-1.Conclusion:Leucoson Tablets are effective in treating primary Sjögren's syndrome complicating peripheral leukocyte reduction.

　　【Keywords】 primary Sjögren's syndrome;Leucoson Tablets;cyclosporine A;peripheral blood leucocytes