来源：风湿病与关节炎,2018,7（3）:32-35.

扶正化瘀通络汤联合来氟米特片治疗老年类风湿关节炎

40例临床观察（临床研究）

刘倩颖，曹永芬，姚血明，马武开

　　【摘　要】目的：观察扶正化瘀通络汤联合来氟米特片治疗老年类风湿关节炎的临床疗效。方法：选取60岁以上类风湿关节炎患者80例，随机分为治疗组和对照组，每组40例。对照组给予口服来氟米特治疗，治疗组在对照组基础上给予扶正化瘀通络汤治疗。2组均以12周为1个疗程。观察2组临床疗效，以及治疗前后症状、体征、炎症因子等指标。结果：治疗组脱落2例，对照组脱落4例。治疗组显效23例，有效10例，无效5例，总有效率为86.84%；对照组显效19例，有效9例，无效8例，总有效率为77.78%。2组比较，差异有统计学意义（P < 0.05）。治疗后，2组症状、体征及炎性指标较治疗前均有改善（P < 0.01或P < 0.05），且治疗组明显优于对照组（P < 0.05）。治疗过程中治疗组5例、对照组9例出现不同程度的不良反应。结论：扶正化瘀通络汤联合来氟米特治疗老年类风湿关节炎临床疗效优于单独服用来氟米特，不仅可以辅助提高疗效，同时可明显缓解来氟米特的副作用，疗效显著，安全可靠。

　　【关键词】　关节炎，类风湿；老年；扶正化瘀通络汤；来氟米特；临床疗效

Clinical Observation on 40 Cases of Senile Rheumatoid Arthritis Treated with Fuzheng Huayu Tongluo Tang（扶正化瘀通络汤）Combining Leflunomide Tablets

LIU Qian-ying,CAO Yong-fen,YAO Xue-ming,MA Wu-kai

　　【ABSTRACT】Objective:To observe the clinical efficacy of Fuzheng Huayu Tongluo Tang（扶正化瘀通络汤）combining Leflunomide Tablets in the treatment of senile rheumatoid arthritis.Methods:Eighty patients over sixty years old with rheumatoid arthritis were randomly divided into a treatment group and a control group,with 40 cases in each.The control group was orally given leflunomide,and the treatment group was treated with Fuzheng Huayu Tongluo Tang based on the treatment for the control group.The two groups were treated with 12 weeks as a course.The clinical effects of the two groups were observed,as well as the symptoms,signs,and inflammatory factors before and after the treatment.Results:There were 2 cases in the treatment group and 4 cases in the control group called off.In the treatment group,23 cases were markedly effective,10 cases were effective,5 cases were invalid,and the total effective rate was 86.84%.In the control group,19 cases were markedly effective,9 cases were effective,8 cases were ineffective,and the total effective rate was 77.78%.The difference between the two groups was statistically significant（P < 0.05）.After treatment,the symptoms,signs and inflammatory indexes of the two groups were improved（P < 0.01 or P < 0.05）,and the treatment group was obviously better than the control group（P < 0.05）.Five cases in the treatment group and nine cases in the control group had different levels of adverse reactions.Conclusion:Fuzheng Huayu Tongluo Tang combining leflunomide Tablets is better than leflunomide alone in the treatment of senile rheumatoid arthritis.It can not only help improve the curative effect,but also relieve the side effects of leflunomide,which is effective,safe and reliable.

　　【Keywords】 arthritis,rheumatoid;senile;Fuzheng Huayu Tongluo Tang（扶正化瘀通络汤）;leflunomide;clinical efficacy