来源：风湿病与关节炎,2018,7（3）:13-17.

类风湿关节炎共病的临床特点及危险因素分析（临床研究）

张旭飞^1,2，李振彬²，刁玉晓^1,2，牛雪敏^2,3，董　琪^2,3，刘　旭^2,3

　　【摘　要】目的：分析类风湿关节炎患者共存疾病（共病）的临床特点及其相关危险因素。方法：选取2016年1月至2016年12月住院类风湿关节炎患者128例，参照ICD-10标准以出院病例首页为依据记录类风湿关节炎共病的分类构成；进一步对患者一般人口学资料、类风湿关节炎疾病特征和实验室检查参数等采用SPSS 19.0软件进行统计分析。结果：类风湿关节炎共病患者101例（78.91%），共病患病率由高到低依次为骨关节炎55例（42.97%），高血压病35例（27.34%），高脂血症26例（20.31%），心血管疾病（包括冠心病、心律失常、心肌缺血）25例（19.53%），脂肪肝22例（17.19%），2型糖尿病18例（14.06%）。Logistic回归分析示：年龄是类风湿关节炎患者合并骨关节炎、高血压病、脂肪肝、2型糖尿病及肺间质纤维化的相对危险因素；体质量是合并高血压病及脂肪肝的相对危险因素；病程是合并高脂血症、骨质疏松症及心血管疾病的相对危险因素；红细胞沉降率是合并2型糖尿病的相对危险因素。结论：类风湿关节炎共病的发生率较高、病种分布广泛，其发生的危险因素除与年龄、病程、体质量等指标相关外，还与类风湿关节炎疾病本身相关。

　　【关键词】　关节炎，类风湿；共病；临床特点；危险因素

Analysis of the Clinical Characteristics and Risk Factors in Rheumatoid Arthritis with Multimorbidity

ZHANG Xu-fei,LI Zhen-bin,DIAO Yu-xiao,NIU Xue-min,DONG Qi,LIU Xu

　　【ABSTRACT】Objective:To explore the clinical features and associated factors in rheumatoid arthritis（RA）patients with multimorbidity.Methods:One hundred and twenty-eight patients with RA were selected between January 2016 to December 2016.RA multimorbidity that were recorded according to the ICD-10 standard.SPSS 19.0 was used to analyze the General demographic data,RA disease characteristics,and laboratory examination parameters of patients.Results:Multimorbidities were found in 101 cases（78.91%） of the participants,The multimorbidity prevalence rate is from high to low in turn osteoarthritis（OA）55 cases（42.97%）,hypertension 35 cases（27.34%）,hyperlipidemia 26 cases（20.31%）,cardiovascular disease（CVD,including coronary heart disease,arrhythmia,myocardial ischemia）25 cases（19.53%）,fatty liver disease（NAFLD）22 cases（17.19%）,type 2 diabetes mellitus（T2DM）18 cases（14.06%）.Multivariate Logistic regression analysis showed that age was the risk factors of RA combined with OA,hypertension,NAFLD,T2DM.Weight was the risk factors of RA combined with hypertension,NAFLD.Disease duration was the risk factors of RA combined with hyperlipidemia,CVD.ESR was the risk factors of RA combined with T2DM.Conclusion:The incidence of RA multimorbidity is very high,the diseases range is wide.The risk factors is associated with age,disease duration and weight,as well as the RA itself.

　　【Keywords】 arthritis,rheumatoid;mu-ltimorbidity;clinical characteristics;risk factors