来源：风湿病与关节炎,2024,13（4）:28-32.

290例强直性脊柱炎患者中医证候的回顾性研究（临床研究）

李其越¹，李湘媛¹，袁盛河¹，曾王星¹，孟凡雨¹，张昊喆¹，殷建美¹，彭江云²

　　【摘　要】目的：研究强直性脊柱炎患者中医证候分布规律，并为辨证分型提供客观证据。方法：选取2018年5月至2022年1月在云南省中医医院风湿科住院的强直性脊柱炎患者290例，收集患者的临床资料、中医证候、实验室指标等。结果：中医证候分布依次为肾虚督寒证、肾虚湿热证、肝肾亏虚证、痰瘀痹阻证。患者年龄与部分实验室检查存在相关性，强直性脊柱炎患者的红细胞沉降率（ESR）、C反应蛋白（CRP）、免疫球蛋白A（IgA）、血清总补体活性（CH50）、胆固醇（CHOL）和低密度脂蛋白（LDL-C）与中医证候存在相关性。结论：痰瘀痹阻证强直性脊柱炎患者的年龄偏大，肾虚湿热证的ESR、CRP、CH50较肝肾亏虚证患者高，CHOL、LDL-C、IgA、CH50与肾虚督寒证、肾虚湿热证、肝肾亏虚证、痰瘀痹阻证的辨证有着紧密联系。

　　【关键词】　强直性脊柱炎；中医证候；回顾性研究；辨证论治

A Retrospective Study on TCM Syndromes in 290 Patients with Ankylosing Spondylitis

LI Qi-yue,LI Xiang-yuan,YUAN Sheng-he,ZENG Wang-xing,MENG Fan-yu,ZHANG Hao-zhe,YIN Jian-mei,PENG Jiang-yun

　　【ABSTRACT】Objective:To study the distribution pattern of traditional Chinese medicine（TCM）syndromes in patients with ankylosing spondylitis and provide objective evidence for syndrome differentiation and classification.Methods:Two hundred and ninety patients with ankylosing spondylitis who were hospitalized in the Rheumatology Department of Yunnan Provincial Hospital of Traditional Chinese Medicine from May 2018 to January 2022 were selected,and their clinical data,TCM syndromes,laboratory indicators,etc.were collected.Results:The distribution of TCM syndromes was in the following order:kidney deficiency and Du cold syndrome,kidney deficiency and damp heat syndrome,liver and kidney deficiency syndrome,and phlegm and blood stasis obstruction syndrome.There was a correlation between patient age and some laboratory tests.ESR,CRP,IgA,CH50,CHOL,and LDL-C of patients with ankylosing spondylitis were correlated with TCM syndromes.Conclusion:Patients with ankylosing spondylitis of phlegm and blood stasis obstruction syndrome are older in age,and the ESR,CRP,and CH50 of kidney deficiency and damp heat syndrome are higher than those of liver and kidney deficiency syndrome.CHOL,LDL-C,IgA,and CH50 are closely related to the differentiation of kidney deficiency and Du cold syndrome,kidney deficiency and damp heat syndrome,liver and kidney deficiency syndrome,and phlegm and blood stasis obstruction syndrome.

　　【Keywords】 ankylosing spondylitis;TCM syndrome;retrospective research;diagnosis and treatment based on syndrome differentiation