来源：风湿病与关节炎,2024,13（4）:1-6.

黄芩清热除痹胶囊对强直性脊柱炎湿热证患者感受、炎症因子及circRNA_0003307的影响（临床研究）

黄　旦^,2，刘　健^1,2,3，汪　元^1,2,3，曹云祥^1,2,3，张皖东^1,2,3，方妍妍¹

　　【摘　要】目的：观察黄芩清热除痹胶囊（HQC）对强直性脊柱炎湿热证患者感受、炎症因子及circRNA_0003307的影响。方法：将60例强直性脊柱炎湿热证患者随机分为治疗组和对照组，每组30例。对照组采用基础治疗，治疗组在对照组基础上联合HQC治疗。观察2组临床疗效（ASAS20、BASDAI50），以及治疗前后疾病活动［视觉模拟评分法（VAS）评分、Bath强直性脊柱炎疾病活动指数（BASDAI）、Bath强直性脊柱炎功能指数（BASFI）、C反应蛋白（CRP）、红细胞沉降率（ESR）］、患者感受评分［生活质量简表（SF-36）、中医证候积分］、炎症因子［肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、IL-17、IL-23］、circRNA_0003307的变化。结果：治疗后，治疗组ASAS20、BASDAI50达标率明显高于对照组（P < 0.05）。与治疗前比较，2组VAS评分、BASDAI、BASFAI、CRP、ESR、SF-36各维度评分、中医证候积分、TNF-α、IL-1β、IL-17、IL-23、circRNA_0003307明显改善（P < 0.05）。与对照组治疗后比较，治疗组BASDAI、情感职能、社会功能、身体疼痛、精力、CRP、IL-23、circRNA_0003307明显改善（P < 0.05）。结论：HQC可能通过调控circRNA_0003307，下调炎症因子TNF-α、IL-1β、IL-17、IL-23表达，抑制免疫炎症反应，改善强直性脊柱炎患者关节功能和患者感受。

　　【关键词】　强直性脊柱炎；黄芩清热除痹胶囊；患者感受；circRNA_0003307；临床疗效

The Effects of Huangqin Qingre Chubi Capsules（黄芩清热除痹胶囊）on the Sensation,Inflammatory Factors,and circRNA_0003307 in Patients with Ankylosing Spondylitis with Damp Heat Syndrome

HUANG Dan,LIU Jian,WANG Yuan,CAO Yun-xiang,ZHANG Wan-dong,FANG Yan-yan

　　【ABSTRACT】Objective:To observe the effects of Huangqin Qingre Chubi Capsules（黄芩清热除痹胶囊,HQC）on the sensation,inflammatory cytokines,and circRNA_0003307 in patients with ankylosing spondylitis with damp heat syndrome.Methods:Sixty patients of ankylosing spondylitis with damp heat syndrome were randomly divided into a treatment group and a control group,30 cases in each.The control group received basic treatment,while the treatment group was treated with HQC in combination with the treatment like that for the control group.An observation was made about the clinical effect（ASAS20,BASDAI50）,as well as disease activity before and after treatment（VAS,BASDAI,BASFI,CRP,ESR）,patient perception score（SF-36,TCM Syndrome Score）,cytokines（TNF-α,IL-1β,IL-17,IL-23）,and circRNA_0003307.Results:After treatment,the compliance rates of ASAS20 and BASDAI50 in the treatment group were significantly higher than those in the control group（P < 0.05）.Compared with before treatment,VAS,BASDAI,BASFAI,CRP,ESR,SF-36 in all dimensions,TCM syndrome score,TNF-α,IL-1β,IL-17,IL-23,and circRNA_0003307 showed significant improvement（P < 0.05）.Compared with the control group after treatment,the treatment group showed significant improvement in BASDAI,RE,SF,BP,VT,IL-23,CRP,circRNA_0003307（P < 0.05）.Conclusion:HQC may downregulate the expression of inflammatory cytokine TNF-α,IL-1β,IL-17,IL-23 by regulating circRNA_0003307,to inhibit immune inflammatory response and improve joint function and patient sensation in patients with ankylosing spondylitis.

　　【Keywords】 ankylosing spondylitis;Huangqin Qingre Chubi Capsules（黄芩清热除痹胶囊）;patient sensation;circRNA_0003307;clinical efficacy