来源：风湿病与关节炎,2024,13（1）:19-23.

高尿酸血症湿热体质患者代谢特点的相关性研究（临床研究）

赵宇杉¹，王郑杨²，陈珊妮³，林晓蓉¹，张志明¹，郭燕芬¹，陈煜宇¹，吴方真¹，齐张旸¹，宋榕斌¹，黄淑敏¹，马慧澜³，赵钟文¹

　　【摘　要】目的：研究高尿酸血症湿热体质患者的代谢特点，为高尿酸血症湿热体质的中医诊疗提供参考。方法：收集2021年2月至2021年12月就诊于福建省第二人民医院风湿内分泌科的高尿酸血症患者100例，分为湿热体质组与非湿热体质组，并检测相关指标。结果：湿热体质组男38例，女2例；非湿热体质组男56例，女4例。2组间年龄比较，差异无统计学意义（P > 0.05）。湿热体质组收缩压（SBP）、舒张压（DBP）、体质量指数（BMI）、内脏脂肪面积（VFA）、双侧肱踝动脉波传导速度（BaPWV）、空腹血糖、甘油三酯、低密度脂蛋白水平高于非湿热体质组，差异有统计学意义（P < 0.05）；2组间总胆固醇及高密度脂蛋白水平比较，差异无统计学意义（P > 0.05）。二元Logistic回归分析显示，高尿酸血症患者VFA、低密度脂蛋白水平与湿热体质的产生呈正相关；高尿酸血症合并内脏脂肪型肥胖（VFO）、动脉硬化、高血压、高甘油三酯血症会增加湿热体质的产生风险。结论：高尿酸血症湿热体质与代谢异常具有相关性。高尿酸血症湿热体质患者在SBP、DBP、BMI、VFA、BaPWV、空腹血糖、甘油三酯及低密度脂蛋白方面较非湿热体质患者升高，但在总胆固醇、高密度脂蛋白方面无明显差异。HUA患者的VFA、低密度脂蛋白水平和湿热体质的产生呈正相关，若合并VFO、动脉硬化、高血压病、高甘油三酯血症会增加湿热体质的产生风险。

　　【关键词】　高尿酸血症；湿热体质；代谢综合征；代谢特点

A Correlation Study on Metabolic Characteristics of Patients with Hyperuricemia and Damp Heat Constitution

ZHAO Yu-shan,WANG Zheng-yang,CHEN Shan-ni,LIN Xiao-rong,ZHANG Zhi-ming,GUO Yan-fen,CHEN Yu-yu,WU Fang-zhen,QI Zhang-yang,SONG Rong-bin,HUANG Shu-min,MA Hui-lan,ZHAO Zhong-wen

　　【ABSTRACT】Objective:To study the metabolic characteristics of patients with hyperuricemia and damp heat constitution,and provide reference for the TCM diagnosis and treatment.Methods:One hundred patients with hyperuricemia who visited the Rheumatology and Endocrinology Department of the Second People’s Hospital of Fujian Province from February 2021 to December 2021 were collected and divided into a damp heat constitution group and a non damp heat constitution group,and relevant indicators were tested.Results:There were 38 males and 2 females in the damp heat constitution group;56 males and 4 females in the non damp heat constitution group.There was no statistically significant difference in age between the two groups（P > 0.05）.The levels of SBP,DBP,BMI,VFA,bilateral BaPWV,fasting blood glucose,triglycerides,and low-density lipoprotein in the damp heat constitution group were higher than those in the non damp heat constitution group,and the differences were statistically significant（P < 0.05）.There was no statistically significant difference in total cholesterol and high-density lipoprotein levels between the two groups（P > 0.05）.Binary logistic regression analysis showed that the levels of VFA and low-density lipoprotein in HUA patients were positively correlated with the development of damp heat constitution.The combination of HUA and VFO,arteriosclerosis,hypertension,and hypertriglyceridemia increased the risk of developing a damp heat constitution.Conclusion:There is a correlation between HUA damp heat constitution and metabolic abnormalities.Patients with HUA damp heat constitution have higher levels of SBP,DBP,BMI,VFA,BaPWV,fasting blood glucose,triglycerides,and low-density lipoprotein compared to patients with non damp heat constitution,but there is no significant difference in total cholesterol and high-density lipoprotein.The levels of VFA and low-density lipoprotein in HUA patients are positively correlated with the development of damp heat constitution.If combined with VFO,arteriosclerosis,hypertension,and hypertriglyceridemia,it will increase the risk of developing damp heat constitution.

　　【Keywords】 hyperuricemia;damp heat constitution;metabolic syndrome;metabolic characteristics