来源：风湿病与关节炎,2023,12（7）:11-14,47.

八段锦对强直性脊柱炎患者异位骨化及白细胞介素-23水平的影响（临床研究）

田丹丹，王善萍，杨　丽，张婷婷，何　丽，刘天阳，管玉香

　　【摘　要】目的：观察八段锦对强直性脊柱炎患者临床疗效及异位骨化、白细胞介素-23（IL-23）的影响。方法：将40例强直性脊柱患者随机分为观察组和对照组，每组20例。对照组予以塞来昔布胶囊口服治疗，观察组在对照组基础上规律练习八段锦，锻炼6个月。观察2组治疗前后Bath强直性脊柱炎疾病活动度指数（BASDAI）、强直性脊柱炎新疾病活动度评分（ASDAS）、疼痛视觉模拟评分法（VAS）评分、指地距、Schöber试验、炎症指标［C反应蛋白（CRP）、红细胞沉降率（ESR）］、焦虑抑郁量表（SAS、SDS评分）、IL-23、Dickkopf-1（DKK-1）、骨保护素（OPG）。结果：治疗后，与治疗前比较，2组BASDAI、ASDAS、VAS评分、指地距、CRP、ESR、IL-23均显著降低（P < 0.05或P < 0.01），Schöber试验、DKK-1显著升高（P < 0.05或P < 0.01）；观察组BASDAI、ASDAS、VAS评分、指地距、SAS、SDS均显著低于对照组（P < 0.05或P < 0.01），DKK-1、OPG显著高于对照组（P < 0.05或P < 0.01）。结论：八段锦能降低强直性脊柱炎患者的疾病活动度，改善炎症反应，抑制异位骨化，提高关节活动功能，缓解焦虑抑郁情绪，便于临床推广。

　　【关键词】　强直性脊柱炎；八段锦；异位骨化；白细胞介素-23；疾病活动

Influence of Baduanjin on Heterotopic Ossification and IL-23 Level in Patients with Ankylosing Spondylitis

TIAN Dan-dan,WANG Shan-ping,YANG Li,ZHANG Ting-ting,HE Li,LIU Tian-yang,GUAN Yu-xiang

　　【ABSTRACT】Objective:To observe the influence of Baduanjin（a kind of martial arts）on the clinical efficacy of ankylosing spondylitis,heterotopic ossification and interleukin-23（IL-23）.Methods:Forty patients with ankylosing spondylitis were randomly divided into a observation group and a control group,with 20 cases in each group.The control group was given celecoxib capsule orally,and the observation group regularly practiced Baduanjin for 6 months based on the treatment as that for the control group.The BASDAI,ASDAS,VAS,finger-ground distance,Schöber test,inflammatory indicators（CRP,ESR）,anxiety and depression scale（SAS,SDS）,IL-23,DKK-1 and OPG were observed before and after treatment in the two groups.Results:After treatment,BASDAI,ASDAS,VAS,finger-ground distance,CRP,ESR,IL-23 in both groups were significantly reduced（P < 0.05 or P < 0.01）,while Schöber test and DKK-1 were significantly increased（P < 0.05 or P < 0.01）compared with those before treatment.The BASDAI,ASDAS,VAS,finger-ground distance,SAS,and SDS in the observation group were signifi-cantly lower than those in the control group（P < 0.05 or P < 0.01）,while DKK-1 and OPG were significantly higher than those in the control group（P < 0.05 or P < 0.01）.Conclusion:Baduanjin can reduce the disease activity of patients with ankylosing spondylitis,improve inflammatory reaction,inhibit heterotopic ossification,improve joint activity,alleviate anxiety and depression,and facilitate clinical promotion.

　　【Keywords】 ankylosing spondylitis;Baduanjin;heterotopic ossification;interleukin-23;disease activity