来源：风湿病与关节炎,2023,12（2）:15-17,22.

巨噬细胞移动抑制因子在银屑病关节炎疾病活动中的作用研究（临床研究）

余淑娇，熊江彪，李　慧，吴　锐

　　【摘　要】目的：探讨巨噬细胞移动抑制因子（MIF）在银屑病关节炎（PsA）中的表达及其与PsA疾病活动度的相关性。方法：纳入40例PsA患者为PsA组，按照DAS28评分≤2.6分为PsA静止组，DAS28评分 ﹥2.6分为PsA疾病活动组；同时招募年龄、性别匹配的健康体检者20例为健康对照组。采用ELISA法检测研究对象血清MIF、肿瘤坏死因子-α（TNF-α）、红细胞沉降率（ESR）、C反应蛋白（CRP）水平，比较PsA组与健康对照组、PsA疾病活动组与PsA静止组之间实验室指标的差异。结果：PsA组患者血清MIF水平显著高于健康对照组（P ﹤ 0.05），PsA疾病活动组患者血清MIF水平显著高于PsA静止组（P ﹤ 0.05）。PsA组患者外周血TNF-α、ESR、CRP水平显著高于健康对照组（P ﹤ 0.05），PsA疾病活动组患者外周血TNF-α、ESR、CRP水平均高于PsA静止组（P ﹤ 0.05）。MIF水平分别与TNF-α、ESR、CRP水平呈正相关（r = 0.476，P = 0.002；r = 0.465，P = 0.003；r = 0.418，P = 0.007）。结论：血清MIF在PsA患者疾病活动期高表达，MIF可能参与PsA的发生及疾病进展，并与PsA的疾病活动度呈正相关。因此，抑制MIF有望成为PsA治疗的新靶点。

　　【关键词】　银屑病关节炎；巨噬细胞移动抑制因子；疾病活动度；相关性；炎性指标

Study on the Role of Macrophage Migration Inhibitory Factor in the Activity of Psoriatic Arthritis

YU Shu-jiao,XIONG Jiang-biao,LI Hui,WU Rui

　　【ABSTRACT】Objective:To investigate the expression of macrophage migration inhibitory factor（MIF）in psoriatic arthritis（PsA）and its correlation with disease activity of PsA.Methods:Forty patients with PsA were included into the PsA group.According to DAS28 score,they were divided into the PsA static group（DAS28≤2.6）and the PsA disease active group（DAS28 > 2.6）.At the same time,twenty-aged and sex-matched health examinees were recruited into the healthy control group.Detection of the levels of serum MIF,TNF-α,ESR and CRP was made and the comparisons between the PsA group and the healthy control group,between the PsA disease active group and the PsA static group were done to know the differences in laboratory indicators.Results:The serum MIF level of patients in the PsA group was significantly higher than that in the healthy control group（P < 0.05） and the serum MIF level of patients in the PsA disease active group was significantly higher than that in the PsA static group（P < 0.05）.The levels of TNF-α,ESR and CRP in peripheral blood in the PsA group were significantly higher than those of the healthy control group（P < 0.05）.The levels of TNF-α,ESR and CRP in peripheral blood in the PsA disease active group were higher than those of the PsA static group（P < 0.05）.MIF level was positively correlated with the levels of ESR and CRP（r = 0.476,P = 0.002;r = 0.465,P = 0.003;r = 0.418,P = 0.007）.Conclusion:Serum MIF is highly expressed in the active phase of the PsA patients.MIF may participate in the occurrence and progression of PsA,and is positively correlated with the disease activity of PsA.Therefore,inhibition of MIF is expected to become a new target for PsA treatment.

　　【Keywords】 psoriatic arthritis;macrophage migration inhibitory factor;disease activity;relevance;inflammatory index