来源：风湿病与关节炎,2021,10（5）:11-14.

吴斌主任中医师治疗干燥综合征用药规律研究（临床研究）

王　晶¹，易国祥¹，李成荫¹，王莎莎¹，朱丰林¹，曹春辉¹，戴明珠²，戴　敏¹

　　【摘　要】目的：分析吴斌主任中医师治疗干燥综合征的辨证思路与用药规律。方法：收集吴斌主任中医师2012年7月至2019年7月于重庆市中医院门诊治疗干燥综合征的医案，采用IBM SPSS Modeler 18.0统计软件对纳入数据进行频数分析、分层聚类分析、三项关联规则分析，总结处方用药规律。结果：纳入医案共涉及处方901首，药物176味，使用频率 > 30%的药物17味，有知母、北沙参、芦根、菊花、夏枯草、石膏等。高频药物四气五味以寒性、甘味居首位，归经频率 > 30%的有肺、胃、肝、脾经。高频药物聚类分析主要分为两大类。结论：吴斌主任中医师治疗干燥综合征的药物以清肝泻胃为主，益气生津为辅。

　　【关键词】　干燥综合征；用药规律；数据挖掘；吴斌

On WU Bin's Medication Rules in the Treatment of Sjögren's Syndrome

WANG Jing,YI Guo-xiang,LI Cheng-yin,Wang Sha-sha,ZHU Feng-lin,CAO Chun-hui,DAI Ming-zhu,Dai Min

　　【ABSTRACT】Objective:To analyze WU Bin's dialectical thought and medication rule in treating Sjögren's syndrome.Methods:The medical cases of Sjögren's syndrome by director WU Bin from July 2012 to July 2019 were collected from Chongqing Hospital of Chinese Medicine.IBM SPSS Modeler 18.0 was used to make frequency analysis,hierarchical cluster analysis and three related rules analysis to summarize the medication rules.Results:Nine hundred and one cases were included.There were 176 drugs,the frequency of 17 drugs of which was more than 30%,including Zhimu（Rhizoma Anemarrhenae）,Beishashen（Radix Glehniae）,Lugen（Rhizoma Phragmitis）,Juhua（Flos Chrysanthemi）,Xiakucao（Spica Prunellae）,and Shigao（Gypsum Fibrosum）.The top-ranking drugs with high frequency are mainly of cold and sweet.The frequency of channel entry of the lung,stomach,liver and spleen channels was more than 30%.High frequency drug cluster analysis is divided into two main categories.Conclusion:Drugs used in WU Bin's medication are mainly those of clearing liver and descending stomach qi,and supplementing qi and promoting fluid production.

　　【Keywords】 Sjögren's syndrome;medication rule;data mining;WU Bin