来源：风湿病与关节炎,2021,10（4）:17-19.

幼年特发性关节炎患儿血免疫球蛋白E水平变化分析

（临床研究）

江春亚，刘　平，魏　磊，刘翠华

　　【摘　要】目的：研究血清中免疫球蛋白E（IgE）水平升高在幼年特发性关节炎患儿中的临床意义。方法：选取2019年3月至2020年3月在郑州儿童医院就诊的初诊为幼年特发性关节炎患儿75例，分为高IgE组36例和非高IgE组39例。2组均给予常规治疗，结合其临床症状，检测患儿治疗前后白细胞介素（IL）-6、IL-1和肿瘤坏死因子-α（TNF-α）水平。结果：治疗后，2组IL-6、IL-1和TNF-α水平低于治疗前；高IgE组在治疗0.5，1，3，6个月各个时间点IL-6、IL-1和TNF-α水平高于非高IgE组，差异均有统计学意义（P < 0.05）。结论：血清IgE可能成为潜在的监测幼年特发性关节炎的实验室指标，且其水平的高低可能影响幼年特发性关节炎患儿的治疗和预后，对治疗不顺利的患儿需要加强IgE水平的监测。

　　【关键词】　幼年特发性关节炎；免疫球蛋白E；白细胞介素-6；白细胞介素-1；肿瘤坏死因子-α

Changes of Serum IgE Levels in Children with Juvenile Idiopathic Arthritis

JIANG Chun-ya,LIU Ping,WEI Lei,LIU Cui-hua

　　【ABSTRACT】Objective:To study the clinical significance of IgE level in children with juvenile idiopathic arthritis.Methods:Seventy-five children with juvenile idiopathic arthritis firstly treated in Zhengzhou Children's Hospital from March 2019 to March 2020 were selected and divided into a high IgE group（36 cases）and a non-high IgE group（39 cases）which were given the routine treatment.The levels of IL-6,IL-1 and TNF-α were detected before and after treatment.Results:The levels of IL-6,IL-1 and TNF-α in both groups before treatment were higher than those after treatment,and the levels of IL-6,IL-1 and TNF-α in the high IgE group at each time point were higher than those in the non-high IgE group,the differences being statistically significant（P < 0.05）.Conclusion:Serum IgE may become a potential laboratory indicator for monitoring juvenile idiopathic arthritis,and its level may affect the treatment and prognosis of children with juvenile idiopathic arthritis.It is necessary to strengthen the monitoring of IgE level for children with poor treatment.

　　【Keywords】 juvenile idiopathic arthritis;IgE;IL-6;IL-1;TNF-α