来源：风湿病与关节炎,2021,10（2）:5-7,27.

乌头汤治疗肾虚督寒型强直性脊柱炎30例临床观察

（临床研究）

程青青，李　炜，程　鹏，刘兆宜，汪荣盛，沈　逸，秦盈盈，唐小蓉，沈　杰，朱　琦，何东仪，姜　婷

　　【摘　要】目的：观察乌头汤治疗肾虚督寒型强直性脊柱炎的临床疗效。方法：将60例活动期肾虚督寒型强直性脊柱炎患者随机分为治疗组和对照组，每组30例。治疗组口服乌头汤治疗，对照组口服美洛昔康片治疗。2组均以4周为1个疗程。观察2组ASAS20疗效、ASAS40疗效、中医证候疗效，以及治疗前后脊柱痛视觉模拟评分法（VAS）评分、患者自我评价VAS评分、Bath强直性脊柱炎功能指数（BASFI）、Bath强直性脊柱炎活动指数（BASDAI）、中医证候积分等指标，并评估安全性。结果：治疗组ASAS40达标率为33.33%，明显优于对照组的6.67%，2组比较，差异有统计学意义（P < 0.05）。2组中医疗效总有效率均为83.33%，差异无统计学意义（P > 0.05）。治疗后，2组脊柱痛VAS评分、患者自我评价VAS评分、BASFI、BASDAI较治疗前均有一定改善，差异有统计学意义（P < 0.05）；2组间各指标比较，差异无统计学意义（P > 0.05）。结论：乌头汤对肾虚督寒型强直性脊柱炎的临床疗效较好，且安全性高。

　　【关键词】　脊柱炎，强直性；肾虚督寒证；乌头汤；美洛昔康；临床疗效

Clinical Observation on 30 Cases of Ankylosing Spondylitis of Kidney Deficiency and Du Meridian Cold Type Treated with Wutou Tang（乌头汤）

CHENG Qing-qing,LI Wei,CHENG Peng,LIU Zhao-yi,WANG Rong-sheng,SHEN Yi,QIN Ying-ying,TANG Xiao-rong,SHEN Jie,ZHU Qi,HE Dong-yi,JIANG Ting

　　【ABSTRACT】Objective:To observe the clinical effect of Wutou Tang（乌头汤）on ankylosing spondylitis of kidney deficiency and Du Meridian cold type.Methods:Sixty cases of active ankylosing spondylitis of kidney deficiency and Du Meridian cold type were randomly divided into a treatment group and a control group,30 cases in each group.The treatment group was treated with Wutou Tang,while the control group was treated with meloxicam tablets.Both groups were treated for 4 weeks as a course.The efficacy of ASAS20 and ASAS40,TCM syndrome efficacy,and evaluate the security,visual analogue scale（VAS）score of spinal pain,VAS score of patients' self-evaluation,Bath Ankylosing Spondylitis Functional Index（BASFI）,Bath Ankylosing Spondylitis Activity Index（BASDAI）,TCM syndrome score and other indicators were observed before and after treatment in the two groups.Results:The compliance rate of ASAS40 in the treatment group was 33.33%,which was significantly better than 6.67% in the control group,and the difference was statistically significant（P < 0.05）.The total effective rate of the two groups was 83.33%,and the difference was not statistically significant（P > 0.05）.After treatment,the VAS,VAS score of spinal pain,VAS score of patients' self-evaluation,BASDAI and BASFI of the two groups were improved compared with those before treatment,and the difference was statistically significant（P < 0.05）,but there was no significant difference between the two groups（P > 0.05）.Conclusion:Wutou Tang is effective and safe in treating ankylosing spondylitis of kidney deficiency and Du Meridian cold type.

　　【Keywords】 spondylitis,ankylosing;kidney deficiency and Du Meridian syndrome;Wutou Tang（乌头汤）;meloxicam;clinical efficacy